Molecular mechanisms and effects of X-ray and particle beam for invasiveness in glioblastoma cell

用X射线或碳离子束照射人胶质母细胞瘤细胞系。不仅X射线，但碳离子束在照射后24小时增加细胞的运动性。堵塞。-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）型谷氨酸受体抑制胶质母细胞瘤细胞的迁移。辐射和谷氨酸受体拮抗剂改变了E-和N-钙粘蛋白的表达。这些结果表明，谷氨酸和钙粘蛋白可能发挥作用，促进胶质母细胞瘤细胞运动的辐射。谷氨酸受体拮抗剂可能是胶质母细胞瘤放射治疗中细胞迁移的有效抑制剂。

Human glioblastoma cell lines were irradiated with X-rays or carbon ion beams. Not only X-rays but carbon ion beams increased cell motility at 24 hours after irradiation. Blockage of .-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor suppressed migration in glioblastoma cells. Expression of E-and N-cadherin proteins was changed by irradiation and glutamate receptor antagonist. These results suggest that glutamate and cadherin might play a role in facilitation of glioblastoma cell motility by irradiation. And also, glutamate receptor antagonist may useful inhibitor for cell migration in radiation therapy of glioblastoma.