Development of high sensitive MRI contrast agent encapsulating CEST agent into apoferritin cavity

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Lanthanoid complexes having various electric charges were newly designed and synthesized as new chemical exchange and saturation transfer(CEST) agents. The complexes were encapsulated into apoferritin cavity, and thier character as CEST type MRI contrast agent was evaluated in vitro. Further, surface of apoferritin is modified with hydrophilic polymers to extend its blood circulation behavior, and I succeeded to deliver the dextran-coated apoferritin to transplanted tumor region utilizing enhanced permeation and retention(EPR) effect. Performance of the apoferritin MRI contrast agent encapsulating CEST agent in vivo was examined using tumor-transplanted mouse.