Optimization of loading superabsorbent polymer microspheres with anticancer drugs for use in chemoembolization of liver tumors unresponsive to standard therapy

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The purpose of this study was to optimize the preparation for loading superabsorbent polymer (SAP) microspheres with anticancer drugs as an efficient drug delivery system for use in chemoembolization of liver tumors unresponsive to standard therapy in clinical practice. Iodinated contrast medium, nonionic isosmotic iodinated contrast medium and undiluted irinotecan solutions for intravenous drip infusion were most suitable for solvent in loading SAP microspheres with cisplatin, epirubicin and irinotecan, respectively. This result of in vivo study in a rabbit model with transplanted liver VX2 tumors suggested that chemoembolization with anticancer drug-loaded SAP microspheres was more effective in suppressing the tumor growth.