Improvement of graft regeneration with partial congestion in living donor liver transplantation

活体肝移植中局部充血移植物再生的改善

• 批准号: 22791269
• 负责人: KIMURA Masaki
• 金额: $ 1.91万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791269/
• 关键词: 生体肝移植; うっ血肝; 肝再生

Hepatic venous congestion after living donor liver transplantation can cause primary non function. We evaluated the effectiveness of granulocyte-colony stimulating factor(G-CSF) for regeneration of remnant liver with venous congestion after hepatectomy in the past. But we were distressed to be established the model of living donor partial liver transplantation between rats. There were no living rats after 40% weight graft after transplantation. We have been making a model of living donor whole liver transplantation with partial congestion between rats. And we prepare for living donor liver transplantation in porcine model.

活体肝移植术后肝静脉淤血可引起原发性肝功能不全。我们过去曾评估粒细胞集落刺激因子（G-CSF）对肝切除术后静脉淤血的残肝再生的有效性。但活体大鼠部分肝移植模型的建立一直困扰着我们。移植后40%重量移植无存活大鼠。我们建立了大鼠间部分淤血的活体全肝移植模型。为活体肝移植的建立做好准备。

项目成果

Preoperative Granulocyte-Colony Stimulating Factor (G-CSF) Treatment Improves Congested Liver Regeneration

• DOI: 10.1016/j.jss.2008.09.002
• 发表时间: 2010-01-01
• 期刊: JOURNAL OF SURGICAL RESEARCH
• 影响因子: 2.2
• 作者: Kimura, Masaki;Yamada, Takuya;Takemura, Hirofumi
• 通讯作者: Takemura, Hirofumi