Development of novel adoptive cell therapy using antigen receptor engineering T cells for chemo/radiotherapy-resistant esophageal cancer

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We performed analysis of samples from the clinical trail patients administrated TCR(T cell receptor)-gene transduced lymphocytes and researched on adoptive cell therapy of tumor-specific lymphocytes using mouse model. In the clinical trail patients, TCR-transduced lymphocytes were detected in their peripheral blood as approximately 1% of PBMC. The infused cells have been in vivo persisted in all patients as long as 10 months. In the adoptive cell therapy model of TCR transgenic mouse, presence of CD4+ T cells or integrin signals is elevated CD8+ T cell multifunctionality, and enhanced anti-tumor effect. Furthermore, we have almost established mouse model of the adoptive transfer of TCR-gene transduced lymphocytes.