Relations between hyaluronan metabolism and CD44 in lung cancer.

肺癌中透明质酸代谢与CD44的关系。

• 批准号: 22791307
• 负责人: MAEDA Sumiko
• 金额: $ 1.75万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791307/
• 关键词: 肺癌; ヒアルロン酸; CD44

We studied relations between immunoreactivities for CD44std, CD44v6, and galectin-9 in lung cancer tissues and their histological types, degree of differenciation, pathological staging, and prognosis. Majority of squamous cell carcinoma was immunoreactive of CD44std and CD44v6, while it was less immunoreactive for galectin-9. In contrast, adenocarcinoma was much less immunoreactive for CD44std and CD44v6 than squamous cell carcinoma. However, it was mostly immunoreactive for galectin-9. Our results suggested that squamous cell carcinoma had a different behavior to extracellular matrix such as hyaluronan from adenocarcinoma, and also indicated a possible negative regulation between CD44 and galectin-9 in lung cancer tissues.

我们研究了肺癌组织中CD44std、CD44v6和半凝集素-9的免疫反应性与其组织学类型、分化程度、病理分期和预后的关系。大多数鳞状细胞癌对CD44std和CD44v6免疫反应，而对半乳糖凝集素-9免疫反应较低。相比之下，腺癌对CD44std和CD44v6的免疫反应远低于鳞状细胞癌。然而，它主要对半乳糖凝集素-9有免疫反应。我们的研究结果表明，鳞状细胞癌与腺癌对透明质酸等细胞外基质的行为不同，并且在肺癌组织中CD44和半凝集素-9之间可能存在负调控。

项目成果

Masami Sato Preferred surgical approach for dumbbell-shaped tumors in the posterior mediastinum

佐藤正美 后纵隔哑铃形肿瘤的首选手术入路

• 发表时间: 2011
• 期刊: Annals of Thoracic and Cardiovascular Surgery
• 影响因子: 1.3
• 作者: Sumiko Maeda;Satomi Takahashi;Kaoru Koike;Masami Sato
• 通讯作者: Masami Sato

Successful closure of an open-window thoracostomy wound by negative-pressure wound therapy

负压伤口治疗成功闭合开窗胸廓造口伤口

• 发表时间: 2012
• 期刊: report of a case Surg Today
• 作者: Sumiko Maeda;Tetsu Sado;Akira Sakurada;Yoshinori Okada;Takashi Kondo
• 通讯作者: Takashi Kondo

重症筋無力症に対する胸腔鏡下拡大胸腺摘出術の効果

胸腔镜扩大胸腺切除术治疗重症肌无力的效果

• 发表时间: 2010
• 作者: 前田寿美子、松村輔二、佐渡哲;他7名
• 通讯作者: 他7名

Surgical treatment for locally advanced lung cancer in a human immunodeficiency virus-infected patient

人类免疫缺陷病毒感染患者局部晚期肺癌的手术治疗

• 发表时间: 2011
• 期刊: Gen Thoracic Cardiovasc Surg
• 作者: Sumiko Maeda;Yoshinori Okada;Akira Sakurada;Tetsu Sado;Hisashi Oishi;Yugo Ashino;Takashi Kondo
• 通讯作者: Takashi Kondo

気管支鏡下に高周波スネアにて切除した気管支軟骨脂肪腫の1例

支气管镜下高频圈套器切除支气管软骨脂肪瘤一例

• 发表时间: 2010
• 期刊: 気管支学
• 作者: 前田寿美子;高橋里美;松原信行;前門土任;佐藤雅美
• 通讯作者: 佐藤雅美