Relations between hyaluronan metabolism and CD44 in lung cancer.

我们研究了肺癌组织中CD44std、CD44v6和半凝集素-9的免疫反应性与其组织学类型、分化程度、病理分期和预后的关系。大多数鳞状细胞癌对CD44std和CD44v6免疫反应，而对半乳糖凝集素-9免疫反应较低。相比之下，腺癌对CD44std和CD44v6的免疫反应远低于鳞状细胞癌。然而，它主要对半乳糖凝集素-9有免疫反应。我们的研究结果表明，鳞状细胞癌与腺癌对透明质酸等细胞外基质的行为不同，并且在肺癌组织中CD44和半凝集素-9之间可能存在负调控。

We studied relations between immunoreactivities for CD44std, CD44v6, and galectin-9 in lung cancer tissues and their histological types, degree of differenciation, pathological staging, and prognosis. Majority of squamous cell carcinoma was immunoreactive of CD44std and CD44v6, while it was less immunoreactive for galectin-9. In contrast, adenocarcinoma was much less immunoreactive for CD44std and CD44v6 than squamous cell carcinoma. However, it was mostly immunoreactive for galectin-9. Our results suggested that squamous cell carcinoma had a different behavior to extracellular matrix such as hyaluronan from adenocarcinoma, and also indicated a possible negative regulation between CD44 and galectin-9 in lung cancer tissues.