The role of TGF-βand approaches of new pharmacological treatments on cerebral aneurysm formation

TGF-β对脑动脉瘤形成的作用和新的药物治疗方法

• 批准号: 22791347
• 负责人: KANEMATSU Yasuhisa
• 金额: $ 2.5万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791347/
• 关键词: 脳動脈瘤; TGF-β

Transforming growth factor-beta(TGF-b) is a kind of cytokines. It is associated with the growth and rupture of aortic artery aneurysms(AAA). TGF-b is thought to be as a promising therapeutic target against AAA, however its role on cerebral aneurysms remains obscure. Using our aneurismal model, we observed the up-regulation of TGF-b in the aneurismal wall and the enhancement of it by pharmacological treatment, suggesting that TGF-b may is a promising therapeutic target on cerebral aneurysms

转化生长因子-β（TGF-β）是一种细胞因子。它与主动脉瘤（AAA）的生长和破裂有关。TGF-β被认为是一个有前途的治疗AAA的靶点，但其在脑动脉瘤中的作用尚不清楚。本实验利用脑动脉瘤模型，观察到脑动脉瘤壁TGF-β表达上调，且药物治疗可使其增强，提示TGF-β可能是治疗脑动脉瘤的一个有希望的靶点

项目成果

Excessive salt-intake exacerbates ischemic brain damage independent of blood pressure

过量盐摄入会加剧缺血性脑损伤，与血压无关

• 发表时间: 2012
• 作者: Sumiyoshi M;Kinouchi T;Tsutsumi T;Kitazato K;Shimada K;Matsushita N;Kanematsu Y;Satomi J;Nagahiro S.
• 通讯作者: Nagahiro S.

ACTIVATION OF NUCLEAR RECEPTORS ON NEUROPROTECTION AFTER EXPERIMENTAL CEREBRAL ISCHEMIA IN FEMALE RATS

雌性大鼠实验性脑缺血后核受体激活对神经保护的作用

• 发表时间: 2012
• 作者: Kohrai M;Kitazato KT.;Kinouchi T;Shimada K;Sumiyoshi M;Matsushita N;Kanematsu Y;Satomi J;Kageji T;Nagahiro S.
• 通讯作者: Nagahiro S.

Pharmacologically induced thoracic and abdominal aortic aneurysms in mice.

• DOI: 10.1161/hypertensionaha.109.140558
• 发表时间: 2010-05
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Kanematsu Y;Kanematsu M;Kurihara C;Tsou TL;Nuki Y;Liang EI;Makino H;Hashimoto T
• 通讯作者: Hashimoto T

High salt-intake under hypoestrogenicity exacerbates ischemic brain damage without affecting the blood pressure

雌激素水平低下的高盐摄入会加剧缺血性脑损伤，但不会影响血压

• 发表时间: 2011
• 作者: Sumiyoshi M;Kitazato KT;Kinouchi T;Tsutsumi T;Shimada K;Matsushita N;Kanematsu Y.;Satomi J.;Nagahiro S.
• 通讯作者: Nagahiro S.

Critical roles of macrophages in the formation of intracranial aneurysm.

• DOI: 10.1161/strokeaha.110.590976
• 发表时间: 2011-01
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Kanematsu Y;Kanematsu M;Kurihara C;Tada Y;Tsou TL;van Rooijen N;Lawton MT;Young WL;Liang EI;Nuki Y;Hashimoto T
• 通讯作者: Hashimoto T