The role of TGF-βand approaches of new pharmacological treatments on cerebral aneurysm formation

转化生长因子-β(TGF-β)是一种细胞因子。它与主动脉瘤(AAA)的生长和破裂有关。转化生长因子-b被认为是一种很有前途的治疗AAA的靶点，但其在脑动脉瘤中的作用尚不清楚。在我们的动脉瘤模型中，我们观察到转化生长因子-β在动脉瘤壁上的表达上调以及药物治疗对其的增强作用，提示转化生长因子-β可能是治疗脑动脉瘤的一个有前景的靶点。

Transforming growth factor-beta(TGF-b) is a kind of cytokines. It is associated with the growth and rupture of aortic artery aneurysms(AAA). TGF-b is thought to be as a promising therapeutic target against AAA, however its role on cerebral aneurysms remains obscure. Using our aneurismal model, we observed the up-regulation of TGF-b in the aneurismal wall and the enhancement of it by pharmacological treatment, suggesting that TGF-b may is a promising therapeutic target on cerebral aneurysms