Social Modulation of Pain in High-sociality Rodents.

草原田鼠是高社会性的啮齿动物，它们形成了强大的配对关系。在这项研究中，田鼠评估，以验证是否社会环境调节疼痛认知。与保持伴侣的雄性田鼠相比，失去伴侣的雄性田鼠在新环境中表现出更高的焦虑水平，机械刺激引起的退缩反射阈值降低，福尔马林引起的伤害性疼痛加剧。这些结果表明，社会环境可以通过情绪变化调节疼痛认知。

Prairie voles are high-sociality rodents, which form strong pair bonds. In this study, the voles were evaluated to verify whether social environment modulates pain cognition. Partner-lost male voles showed higher anxiety levels in novel environment, lower threshold for mechanical stimulation-induced withdrawal reflex, and exacerbation of formalin-induced nociceptive pain as compared to partner-keep males. These results suggest that social environment can modulate pain cognition through emotional changes.