Social Modulation of Pain in High-sociality Rodents.

高社会性啮齿动物疼痛的社会调节。

• 批准号: 22791438
• 负责人: OSAKO Yoji
• 金额: $ 2.5万
• 依托单位: Kochi University (2010, 2012)Aichi Medical University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791438/
• 关键词: 痛み; 社会性; パートナーロス; 情動; ロストシングル; 疼痛性障害; 社会脳; ストレス; 医療・福祉; 獣医学; 行動学; 社会的ストレス

Prairie voles are high-sociality rodents, which form strong pair bonds. In this study, the voles were evaluated to verify whether social environment modulates pain cognition. Partner-lost male voles showed higher anxiety levels in novel environment, lower threshold for mechanical stimulation-induced withdrawal reflex, and exacerbation of formalin-induced nociceptive pain as compared to partner-keep males. These results suggest that social environment can modulate pain cognition through emotional changes.

草原田鼠是高度群居的啮齿动物，它们形成了牢固的伴侣关系。本研究对田鼠进行了评估，以验证社会环境是否调节疼痛认知。失去伴侣的雄性田鼠在新环境中表现出更高的焦虑水平，机械刺激诱发的戒断反射阈值较低，福尔马林诱发的痛觉性疼痛加剧。这些结果表明，社会环境可以通过情绪变化调节疼痛认知。

项目成果

Development of Heat Hyperalgesia and Changes of TRPV1 and NGF Expression in Rat Dorsal Root Ganglion Following Joint Immobilization

• DOI: 10.33549/physiolres.932280
• 发表时间: 2013-01-01
• 期刊: PHYSIOLOGICAL RESEARCH
• 影响因子: 2.1
• 作者: Nishigami, T.;Osako, Y.;Ushida, T.
• 通讯作者: Ushida, T.