Analysis of effects of general anesthetics on TRP receptors aiming at elucidation of action mechanisms of general anesthetics

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We demonstrated that general anesthetics enhanced TRP receptors function, suggesting that effects of general anesthetics on TRP receptors are not related to anesthetic effects. On the other hands, we found that antidepressant, duloxetine for neuropathic pain inhibits the function of TRPM8 receptor, which is one of TRP receptor subtypes. It has been proposed that TRPM8 receptor is related to cold allodynia that is one of neuropathic pain symptom, indicating that inhibition of TRPM8 function may be one of action mechanisms of duloxetine. Development of new analgesics for neuropathic pain can be expected by further investigations about this effect.