Analysis of effects of general anesthetics on TRP receptors aiming at elucidation of action mechanisms of general anesthetics

我们证实了全麻药对Trp受体功能的增强作用，提示全麻药对Trp受体的影响与麻醉作用无关。另一方面，我们发现治疗神经病理性疼痛的抗抑郁药度洛西汀抑制了TRPM8受体的功能，TRPM8受体是Trp受体亚型之一。已有研究提出TRPM8受体与神经病理性疼痛症状之一的冷痛有关，提示抑制TRPM8功能可能是度洛西汀的作用机制之一。通过对这一效应的进一步研究，有望开发出治疗神经病理性疼痛的新镇痛剂。

We demonstrated that general anesthetics enhanced TRP receptors function, suggesting that effects of general anesthetics on TRP receptors are not related to anesthetic effects. On the other hands, we found that antidepressant, duloxetine for neuropathic pain inhibits the function of TRPM8 receptor, which is one of TRP receptor subtypes. It has been proposed that TRPM8 receptor is related to cold allodynia that is one of neuropathic pain symptom, indicating that inhibition of TRPM8 function may be one of action mechanisms of duloxetine. Development of new analgesics for neuropathic pain can be expected by further investigations about this effect.