Analysis of effects of general anesthetics on TRP receptors aiming at elucidation of action mechanisms of general anesthetics

分析全身麻醉药对TRP受体的影响，阐明全身麻醉药的作用机制

• 批准号: 22791461
• 负责人: TERADA Tadanori
• 金额: $ 2.5万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791461/
• 关键词: 麻酔学; TRP受容体; TRPM8受容体; 抗うつ薬; デュロキセチン; 鎮痛機序メカニズム; 全身麻酔薬; TRPA1受容体; 全身麻酔薬の作用機序; イソフルラン; セボフルラン; アフリカツメガエル卵母細胞発現系; TRPV1受容体; カプサイシン

We demonstrated that general anesthetics enhanced TRP receptors function, suggesting that effects of general anesthetics on TRP receptors are not related to anesthetic effects. On the other hands, we found that antidepressant, duloxetine for neuropathic pain inhibits the function of TRPM8 receptor, which is one of TRP receptor subtypes. It has been proposed that TRPM8 receptor is related to cold allodynia that is one of neuropathic pain symptom, indicating that inhibition of TRPM8 function may be one of action mechanisms of duloxetine. Development of new analgesics for neuropathic pain can be expected by further investigations about this effect.

我们证明，全身麻醉药增强TRP受体的功能，这表明全身麻醉药对TRP受体的影响与麻醉作用无关。另一方面，我们发现抗抑郁药度洛西汀对TRP受体亚型之一的TRPM 8受体的功能有抑制作用。有研究认为TRPM 8受体与神经病理性疼痛症状之一的冷异常性疼痛有关，提示TRPM 8功能抑制可能是度洛沙坦的作用机制之一。通过对这一效应的进一步研究，有望开发出治疗神经病理性疼痛的新型镇痛药。