Control of kidney fibrosis in the mouse unilateral urethral obstruction model with the novel AP-1 inhibitor

建立小鼠单侧输尿管梗阻模型。我们评估了UUO术后肾纤维化的自然时间进程。至少从造模后第3天开始，肾髓质和皮质均出现纤维化。与对照组相比，DHMEQ治疗可减少非免疫性肾炎模型中的间质纤维化、肾小管凋亡和增殖。另一方面，与对照组相比，DTCM（十二烷基硫代羰基甲基）没有达到显著的抗肾纤维化作用。我认为需要进一步详细检查给药方法、给药途径和给药期。

The unilateral ureteral obstructive(UUO) model of the mouse was created. We evaluated the natural time course of renal fibrosis after UUO operation. Renal fibrosis was occurred in both renal medulla and cortex at least from the 3rd day after UUO creation. DHMEQ treatment decreased the interstitial fibrosis, tubular apoptosis and proliferation as compared with control group in the non-immune nephritis model. On the other hand, DTCM(dodecylthiocarbonyl methyl) did not achieve the significant effect against the renal fibrosis compared with the control group. I thought that the further detailed examination of the medication method, an administration route, and a dosing period was required.