The elucidation of the physiological polymorphism related to arteriosclerosis by the approach method from genetic and acquired factor

从遗传和后天因素入手的方法阐明与动脉硬化相关的生理多态性

• 批准号: 19370104
• 负责人: MAEDA Takahiro
• 金额: $ 12.06万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19370104/
• 关键词: 生理的多型性; ホモシステイン; 離島; 動脈硬化; メチレンテトラヒドロ葉酸還元酵素; アディポネクチン; ヒストン脱アセチル化酵素; 遺伝子多型; 葉酸; ホモシステイ; 生活習慣病

We conducted the investigation study related to arteriosclerosis in small remote islands with a population of less than 1,000 and large island with a population of about 40,000 in Goto islands, where the environmental factor was considered to be different. Comparing 205 inhabitants in small islands with 2,520 inhabitants in large island after adjustment for age and sex, plasma homocysteine concentration and carotid intima-media thickness was significantly higher in large island, and plasma folic acid concentration was significantly higher in small island. Because there was not a difference by areas regarding the genetic factor related to the metabolism of folic acid, it was suggested that the physiological polymorphism with acquired factor existed.

我们在后藤诸岛中人口不足1，000人的偏远小岛和人口约40，000人的大岛进行了与动脉硬化相关的调查研究，认为环境因素不同。在调整年龄和性别后，将205名小岛屿居民与2，520名大岛居民进行比较，发现大岛的血浆同型半胱氨酸浓度和颈动脉内膜中层厚度显著较高，而血浆叶酸浓度显著较高。由于与叶酸代谢相关的遗传因素没有地区差异，因此认为存在具有后天因素的生理多态性。

项目成果

Physiological polymorphism of arteriosclerosis on a remote Japanese island.

日本偏远岛屿动脉硬化的生理多态性。

• 发表时间: 2008
• 作者: Kusano Y;Nakazato M;Ishibashi K;Takamura N;Nakashima K;Yamasaki H;Oozono Y;Kuwahara K;Nakamura H;Aoyagi K;Maeda T
• 通讯作者: Maeda T

Multimers and adiponectin gene 276G>T polymorphism in the Japanese population residing in rural areas

居住在农村地区的日本人群的多聚体和脂联素基因 276G>T 多态性

• 发表时间: 2007
• 期刊: Clin Chem Lab Med 45(11)
• 作者: Ishibashi K;Takamura N;Aoyagi K;Yamasaki H;Abiru N;Nakazato M;Kamihira S;Maeda T
• 通讯作者: Maeda T

離島住民における赤血球中葉酸とホモシステインとの関連

偏远岛屿居民红细胞中叶酸与同型半胱氨酸的关系

• 发表时间: 2009
• 作者: 中里未央;草野洋介;高村昇;中島憲一郎;青柳潔;大園惠幸;前田隆浩
• 通讯作者: 前田隆浩

Thyroid function is associated with carotid intima-media thickness in euthyroid subjects.

• DOI: 10.1016/j.atherosclerosis.2008.09.022
• 发表时间: 2009-06-01
• 期刊: Atherosclerosis
• 影响因子: 5.3
• 作者: Takamura, Noboru;Akilzhanova, Ainur;Aoyagi, Kiyoshi
• 通讯作者: Aoyagi, Kiyoshi

五島地区の健診者における血清シスタチンCと動脈硬化の関連

五岛地区体检血清胱抑素C与动脉硬化的关系

• 发表时间: 2009
• 作者: 山下裕;古巣朗;西野友哉;小畑陽子;中里未央;高村昇;前田隆浩;大園恵幸;河野茂
• 通讯作者: 河野茂