Mechanism of acquisition of hormone independency of prostate cancer xenograft model established from Japanese patient.

日本患者前列腺癌异种移植模型获得激素独立性的机制。

• 批准号: 22791500
• 负责人: KIMURA Takahiro
• 金额: $ 2.5万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791500/
• 关键词: 前立腺癌; 動物モデル; ホルモン抵抗性

The aim of the study is to elucidate the molecular characteristics of the novel prostate cancer xenograft model from Japanese patient, JDCaP and to establish and analyze the hormone independent subline. Molecular character between JDCaP and cancerous tissue of the patient was revealed similar. The change of molecular character of hormone independent subline was indicated by the analysis.

本研究的目的是阐明日本患者 JDCaP 的新型前列腺癌异种移植模型的分子特征，并建立和分析激素非依赖性亚系。 JDCaP 与患者癌组织之间的分子特征相似。分析表明激素非依赖性亚系分子特征的变化。