Study for biological function in prostate cancer of SND1 and its role for therapeutic target.

SND1在前列腺癌中的生物学功能及其作为治疗靶点的作用研究。

• 批准号: 20791124
• 负责人: KIMURA Takahiro
• 金额: $ 2.58万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791124/
• 关键词: 癌; 泌尿器科; 前立腺癌; バイオマーカー

The aim of the study was to elucidate the biological function of SND1 in prostate cancer. Transgenic mouse expressed SND1 prostate-specifically was produced and the prostate was observed histologically. At the 18 months old, cancer was not observed in the prostate. To observe the molecular change according to SND1 expression, microarray was performed using total RNA extracted from the prostate. Change of expression was compared between TG and control mice and the change was confirmed by real time PCR. Some molecules were identified and thought to have roles in carcinogenesis of prostate cancer.

本研究的目的是阐明SND1在前列腺癌中的生物学功能。制备了前列腺特异性表达SND1的转基因小鼠，并对其进行了前列腺组织学观察。在18个月大的时候，没有发现前列腺癌。为了观察SND1表达的分子变化，我们使用从前列腺中提取的总RNA进行芯片检测。比较TG与对照组小鼠的表达变化，并通过实时PCR证实其变化。一些分子被确定并被认为在前列腺癌的癌变中起作用。