SND1在前列腺癌中的生物学功能及其作为治疗靶点的作用研究。-猫眼课题宝

SND1在前列腺癌中的生物学功能及其作为治疗靶点的作用研究。

批准号：

20791124

负责人：

KIMURA Takahiro

金额：

$2.58万

依托单位：

Jikei University School of Medicine

依托单位国家：

日本

项目类别：

Grant-in-Aid for Young Scientists (B)

财政年份：

2008

资助国家：

日本

项目状态：

已结题

起止时间：

2008 至 2009

来源：

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791124/

关键词：

癌泌尿器科前立腺癌バイオマーカー

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英文摘要

The aim of the study was to elucidate the biological function of SND1 in prostate cancer. Transgenic mouse expressed SND1 prostate-specifically was produced and the prostate was observed histologically. At the 18 months old, cancer was not observed in the prostate. To observe the molecular change according to SND1 expression, microarray was performed using total RNA extracted from the prostate. Change of expression was compared between TG and control mice and the change was confirmed by real time PCR. Some molecules were identified and thought to have roles in carcinogenesis of prostate cancer.

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