Research of signaling mechanism in nasopharyngeal cancer

作为染色质重塑和基因表达的全球调节者，特殊的AT富含结合蛋白1(SATB1)已被认为与促进许多癌症的生长和转移有关。在这里，我们证明了EB病毒(EBV)的主要癌基因潜伏膜蛋白1(LMP1)上调了人鼻咽癌细胞系中SATB1的RNA和蛋白的表达。我们发现鼻咽癌(NPC)患者的组织样本中SATB1蛋白水平升高。综上所述，我们的结果提示SATB1在EBV阳性的鼻咽癌中作为LMP1信号的转移性效应因子发挥作用。

A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein-Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines.We show that SATB1 protein levels are elevated in tissue samplesfrom patients with nasopharyngeal carcinoma (NPC). Taken together, our results suggest that SATB1 functions as a prometastatic effector of LMP1 signalling in EBV-positive NPC.