Functional analyses of G691S RET polymorphism in proliferation and invasion of head and neck cancers

研究证明，酪氨酸受体激酶G691S RET多态通过增强和延长RET下游ERK和AKT的磷酸化，促进头颈癌的增殖和侵袭。结果表明，有神经趋向性的头颈部肿瘤组织中G691S RET基因多态性频率较高。提示G691S RET基因多态性可促进头颈部肿瘤的生长、侵袭或转移。

It was proven that G691S RET polymorphism, one of the tyrosine receptor kinase could enhance the proliferation and invasion of head and neck cancer through enhanced and extended phosphorylation of ERK and AKT in the downstream of RET. It was shown that the samples of head and neck cancers with neurotropism had high frequency of G691S RET polymorphism. The observation suggested G691S RET polymorphism could enhance growth, invasion, or metastasis of head and neck cancers.