Influence between genetic variant of oxidative stress relating gene CYP1A1 and allergic rhinitis

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Oxidative stress is one of a key components of inflammation for upper airway diseases. Diesel exhaust particles(DEP) and asian sand dust increase oxidative stress and influence upper airway disorder including allergic rhinisis. Cytochrom 1A1(CYP1A1) is one of the Cytochrome P450 enzymes, catalyze the biotransformation of a wide variety of xenobiotic compaounds such as DEP and asian sand dust. We screened single-nucleotide polymorphisms(SNPs) at the CYP1A1 locus and performed an association study in the Japanese population.(619 patients with allergic rhinitis, 311 controls) Functional analysis of the SNP using transient transfection reporter gene assay was conducted. We identified 9SNPs at this locus and found this region consisted of one linkage disequilibrium block represented by three SNPs(tag SNPs). The association between the intron 1 polymorphism in the CYP1A1 gene and adult allergic rhinitis was significant.(p=0. 002, OR=1. 51, 95% C. I.=1. 1-1. 7) Risk allele containing construct showed significantly lower induction of CYP1A1 promoter activity in reporter gene assay.(p<0. 01) Our results support a role for CYP1A1 in the pathogenesis of allergic rhinitis in the Japanese population.