Roles and modes of nectins in the development and regeneration of the olfactory epithelium

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The olfactory epithelium, which is located inside the nasal cavity, is a specialized sensory epithelium. In this study, we observed the cellular arrangements of supporting cells and olfactory cells in the developing mouse olfactory epithelium. We found that nectins were distributed in differential and complementary patterns in the apical cell-cell contact sites of the olfactory epithelium. We investigated the effect of a mixed culture experiment of the cells expressing differential adhesion molecules. Various cellular arrangements were formed depending on the adhesion molecules. Thus, we revealed that interactions of nectins are implicated in these cellular rearrangements in the olfactory epithlium.