Intraocular Concentrations of Cytokines and Chemokines in Rhegmatogenous Retinal Detachment and the Effect of Intravitreal Triamcinolone Acetonide

孔源性视网膜脱离眼内细胞因子和趋化因子浓度及玻璃体内注射曲安奈德的影响

• 批准号: 22791648
• 负责人: KUNIKATA Hiroshi
• 金额: $ 2.16万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791648/
• 关键词: サイトカイン; ケモカイン; 硝子体; ステロイド; トリアムシノロンアセトニド; MCP-1; 網膜剥離; 黄斑浮腫; 糖尿病

To determine the aqueous humor levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA)in eyes with rhegmatogenous retinal detachment (RRD).Nineteen eyes of 19 consecutive patients with RRD who underwent IVTA were studied. 17 eyes without retinal vascular disease served as control.The aqueous humor levels of interleukin-6 (IL-6), IL-8, eotaxin, G-CSF, GM-CSF, IFN-gamma, IP-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP-1a), beta (MIP-1b), RANTES, TNF-alpha and vascular endothelial growth factor (VEGF)were determined before the IVTA (baseline)and at one day after the IVTA.At the baseline, IL-6, IL-8, IP-10, MCP-1, MIP-1b and VEGF were detected in the aqueous and were significantly higher in eyes with a RRD than in controls. One day after IVTA, the levels of IP-10, MCP-1 and MIP-1b were significantly reduced and the decreases in IP-10, MCP-1 and MIP-1b were correlated. IVTA was able to suppress the levels of IP-10, MCP-1 and MIP-1b in eyes with RRD. The alterations in the aqueous level of IP-10, MCP-1 and MIP-1b were similar and these chemokines might potentially be additional target molecules in therapy for RRD.

为检测孔源性视网膜脱离（RRD）患者玻璃体腔内注射曲安奈德（IVTA）前后房水中趋化因子的水平，对19例19眼行IVTA的RRD患者进行了研究。检测白细胞介素-6（IL-6）、IL-8、嗜酸性粒细胞趋化因子（eotaxin）、粒细胞集落刺激因子（G-CSF）、粒细胞集落刺激因子（GM-CSF）、干扰素-γ（IFN-γ）、IP-10、单核细胞趋化蛋白-1（MCP-1）、巨噬细胞炎性蛋白-1 α（MIP-1a）、β（MIP-1b）、RANTES、IVTA前测定TNF-α和血管内皮生长因子（VEGF）在基线时，在房水中检测到IL-6、IL-8、IP-10、MCP-1、MIP-1b和VEGF，并且在RRD眼中显著高于对照眼。IVTA后第1天，IP-10、MCP-1和MIP-1b水平显著降低，且IP-10、MCP-1和MIP-1b的降低具有相关性。IVTA能抑制RRD患者IP-10、MCP-1和MIP-1b的水平。IP-10、MCP-1和MIP-1b的水含量变化相似，这些趋化因子可能是RRD治疗中的额外靶分子。

项目成果

巨大裂孔網膜剥離に対するMIVSと20G硝子体手術の比較

MIVS与20G玻璃体切除术治疗巨大裂孔视网膜脱离的比较

• 发表时间: 2011
• 作者: 目黒真里絵;國方彦志;西田幸二;國方彦志
• 通讯作者: 國方彦志

Tumor Necrosis Factor-{alpha} Mediates Photoreceptor Death in a Rodent Model of Retinal Detachment

肿瘤坏死因子-{α}介导视网膜脱离啮齿动物模型中的感光细胞死亡

• 发表时间: 2011
• 期刊: Invest Ophthalmol Vis Sci
• 作者: Nakazawa T;Kayama M;Ryu M;Kunikata H;Watanabe R;Yasuda M;Kinugawa J;Vavvas D;Miller JW.
• 通讯作者: Miller JW.

「未治療例の硝子体手術」新ESNOW 糖尿病網膜症治療最前線

“针对未经治疗的病例进行玻璃体手术”新ESNOW：糖尿病视网膜病变治疗的最前沿

• 发表时间: 2011
• 作者: 國方彦志;新田文彦;目黒泰彦;相澤奈帆子;針谷威寛;千葉真生;阿部俊明(東北大);西田幸二(大阪大);國方彦志
• 通讯作者: 國方彦志

Preoperative Findings in Patients with Idiopathic Macular Epiretinal Membrane Predictive of Good Postoperative Visual Acuity after 25-gauge Vitrecotmy

特发性黄斑视网膜前膜患者的术前发现可预测 25 号玻璃体切割术后良好的术后视力

• 发表时间: 2011
• 期刊: Clin Ophthalmol
• 影响因子: 2.2
• 作者: Kunikata H;Abe T;Kinukawa J and Nishida K
• 通讯作者: Kinukawa J and Nishida K

潰瘍性大腸炎に併発し自然軽快がみられた網膜中心静脈閉塞症の一例

伴随溃疡性结肠炎发生并自行消退的视网膜中央静脉阻塞一例。

• 发表时间: 2010
• 期刊: 眼科紀要
• 作者: 目黒真里絵;國方彦志;西田幸二
• 通讯作者: 西田幸二