Search for the mechanism of dry eye disease using active oxygen excessive model mouse

Tet-mev-1小鼠泪液分泌减少，形态学改变。与野生型小鼠相比，Tet-mev-1小鼠的撕裂量值较低。与野生型小鼠相比，Tet-mev-1小鼠泪腺分泌过量的超氧阴离子（O & _2^-）和氧化蛋白。组织病理学分析显示，Tet-mev-1小鼠泪腺中8-OHdG抗体染色的腺泡细胞周围存在强烈的单核白细胞浸润和纤维化，具有泪腺炎症的特征。这些发现有力地表明，氧化应激可能是干眼病发展的一个致病因素。

Tet-mev-1 mice revealed decreased tear production with the morphological changes. Tear quantity values in Tet-mev-1 mice were lower compared to the wild type mice. The lacrimal gland of Tet-mev-1 mice overproduced superoxide anion(O & _2^-) and oxidative protein compared to the wild type mice. Histopathological analyses showed the hallmarks of lacrimal gland inflammation by presence of intense mononuclear leukocytic infiltration and fibrosis around acinar cell staining by 8-OHdG antibody in the lacrimal gland of Tet-mev-1 mice. These findings strongly suggest that oxidative stress can be a causative factor for the development of dry eye disease.