The utility of the Hh protein as the new serum tumor marker in the childhood solid cancer

Hh蛋白作为新的血清肿瘤标志物在儿童实体癌中的应用

• 批准号: 22791710
• 负责人: SOUZAKI Ryota
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791710/
• 关键词: 神経芽腫; hedgehog signal; 血清腫瘍マーカー; Hhシグナル; Hedgehog signal

The hedgehog(Hh) signaling pathway plays an important role in the growth and patterning in a variety of tissues during embryonic development. On the other hand, the activation of the Hh signal pathway due to mutations or ligand-dependent stimulation of the pathway is associated with tumorigenesis of a lot of cancers. This study revealed that 67-79% neuroblastoma samples showed positive for Hh proteins. There was a significant association between Oh signal proteins and the status of MYCN gene. The percentage of Oh protein positive cells in early stage samples was higher than that with advanced stage. The 5-year OS rate of Hh protein positive cases without MYCN amplification is significantly higher than that inGLI1 negative cases. Based on these result, the Hh signal proteins are possible to be a serum marker of neuroblastoma.

刺猬（Hh）信号通路在胚胎发育过程中的各种组织的生长和图案化中起着重要的作用。另一方面，由于Hh信号通路的突变或配体依赖性刺激而引起的Hh信号通路的激活与许多癌症的肿瘤发生相关。这项研究表明，67-79%的神经母细胞瘤样品显示Hh蛋白阳性。OH信号蛋白的表达与MYCN基因的状态有显著相关性。早期胃癌组织中OH蛋白阳性细胞百分率高于晚期胃癌组织。Hh蛋白阳性而无MYCN扩增者的5年OS率显著高于GLI 1阴性者。提示Hh信号蛋白有可能作为神经母细胞瘤的血清标志物。

项目成果

Interval appendectomyの至適待機期間について

关于间隔阑尾切除术的最佳等待期

• 发表时间: 2011
• 作者: 宗崎良太;家入里志;松浦俊治;永田公二;林田真;木ド義晶;田尻達郎;田口智章
• 通讯作者: 田口智章

当科で経験した膵外傷症例の検討

我科经历​​的胰腺外伤病例检查

• 发表时间: 2011
• 作者: 宗崎良太;木下義晶;林田真;松浦俊治;田口智章
• 通讯作者: 田口智章

The number of Segmental Chromosome Aberrations Significantly Increases in Proportion To the Age at Diagnosis in Subjects with Diploid/Tetraploid Neuroblastomas without MYCN Amplification

在没有 MYCN 扩增的二倍体/四倍体神经母细胞瘤受试者中，节段性染色体畸变的数量与诊断时年龄的比例显着增加

• 发表时间: 2011
• 作者: Souzaki R;Tajiri T;Teshiba R;Kinoshita Y;Yosue R;Kohashi K;Oda Y;TaguchiT
• 通讯作者: TaguchiT

Hedgehog signaling pathway in neuroblastoma differentiation

• DOI: 10.1016/j.jpedsurg.2010.08.020
• 发表时间: 2010-12-01
• 期刊: JOURNAL OF PEDIATRIC SURGERY
• 影响因子: 2.4
• 作者: Souzaki, Ryota;Tajiri, Tatsuro;Taguchi, Tomoaki
• 通讯作者: Taguchi, Tomoaki

Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy

• DOI: 10.1593/neo.10458
• 发表时间: 2010-10-01
• 期刊: NEOPLASIA
• 影响因子: 4.8
• 作者: Fujita, Hayato;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao