The utility of the Hh protein as the new serum tumor marker in the childhood solid cancer

刺猬（Hh）信号通路在胚胎发育过程中的各种组织的生长和图案化中起着重要的作用。另一方面，由于Hh信号通路的突变或配体依赖性刺激而引起的Hh信号通路的激活与许多癌症的肿瘤发生相关。这项研究表明，67-79%的神经母细胞瘤样品显示Hh蛋白阳性。OH信号蛋白的表达与MYCN基因的状态有显著相关性。早期胃癌组织中OH蛋白阳性细胞百分率高于晚期胃癌组织。Hh蛋白阳性而无MYCN扩增者的5年OS率显著高于GLI 1阴性者。提示Hh信号蛋白有可能作为神经母细胞瘤的血清标志物。

The hedgehog(Hh) signaling pathway plays an important role in the growth and patterning in a variety of tissues during embryonic development. On the other hand, the activation of the Hh signal pathway due to mutations or ligand-dependent stimulation of the pathway is associated with tumorigenesis of a lot of cancers. This study revealed that 67-79% neuroblastoma samples showed positive for Hh proteins. There was a significant association between Oh signal proteins and the status of MYCN gene. The percentage of Oh protein positive cells in early stage samples was higher than that with advanced stage. The 5-year OS rate of Hh protein positive cases without MYCN amplification is significantly higher than that inGLI1 negative cases. Based on these result, the Hh signal proteins are possible to be a serum marker of neuroblastoma.