The scavengering effect of edaravone to nitric monoxide in mice traumatic brain injury

Mice were subjected to controlled cortical impact（CCI）production was obvious by3hours post-CCI，with oxidative stress and neuronal cell death becoming apparent after 6 hours. Therefore，edaravone (3.0mg/kg) or saline as a vehicle was administered intravenously either immediately（0hours） or 3 or 6 hours post-CCI. Administration of edaravone 0,3 or 6 hours post-CCI resulted in a重大减少in the injury volume and level of oxidative stress compared with the control。The greatest decrease in o_2 levels was observed when edaravone was administered 3 hourspost-CCI. The current findings suggest that CCI produces excessive o_2leading to oxidative stress and neuronal cell death. However these effects can be ameliorated byedaravone treatment， particularly if the drug is administered 3小时post-CCI。

Mice were subjected to controlled cortical impact(CCI). Post-CCI, O_2^<・->production was obvious by3hours post-CCI, with oxidative stress and neuronal cell death becoming apparent after 6 hours. Therefore, edaravone (3.0mg/kg) or saline as a vehicle was administered intravenously either immediately (0hours) or 3 or 6 hours post-CCI. Administration of edaravone 0,3 or 6 hours post-CCI resulted in a significant reduction in the injury volume and level of oxidative stress compared with the control. The greatest decrease in O_2^<・->levels was observed when edaravone was administered 3 hours post-CCI. The current findings suggest that CCI produces excessive O_2^<・->, leading to oxidative stress and neuronal cell death. However these effects can be ameliorated by edaravone treatment, particularly if the drug is administered 3 hours post-CCI.