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The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass

The role of anti-apoptotic Bcl-X_L in bone formation and maintenance of bone mass
抗凋亡Bcl-X_L在骨形成和骨量维持中的作用
批准号:
22791771
负责人:
MORIISHI Takeshi
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
In the present study, we generated transgenic mice with osteoblasts that express anti-apoptotic BCL-X_L. In BCL-X_L transgenic mice, bone volume was increased at 10 weeks of age and recognized maintenance of the bone volume at aging mice. In the recent aging society, bone volume decrease by the osteoporosis becomes the big social problem, therefore Bcl-X_L may become the target for the osteoporosis treatment in the future.
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会议论文
Ultrastructural analysis of osteoblasts, osteocytes and odontoblasts in Runx2 transgenic mice.
Runx2 转基因小鼠中成骨细胞、骨细胞和成牙本质细胞的超微结构分析。
DOI: --
发表时间: 2009
期刊: 6th international Symposium on Electron Microscopy in Medicine and Biology, Kobe, Japan
影响因子: --
作者: [Miyazaki, T, Moriishi, T, Izumi, S, Baba, T, Komori, T]
通讯作者: T
DOI: 10.1007/s00774-011-0268-6
发表时间: 2011-11-01
期刊: JOURNAL OF BONE AND MINERAL METABOLISM
影响因子: 3.3
作者: [Cao, Lei, Moriishi, Takeshi, Yamaguchi, Akira]
通讯作者: Yamaguchi, Akira
骨芽細胞分化における抗アポトーシス分子Bcl-2の役割
抗凋亡分子Bcl-2在成骨细胞分化中的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Muraki S, Akune T, Ishimoto Y, Nagata K, Yoshida M, Tanaka S, Oka H, Kawaguchi H, Nakamura K, and Yoshimura N, 森石武史]
通讯作者: 森石武史
DOI: 10.1016/j.bone.2011.07.023
发表时间: 2011-10-01
期刊: BONE
影响因子: 4.1
作者: [Maeno, Takafumi, Moriishi, Takeshi, Komori, Toshihisa]
通讯作者: Komori, Toshihisa
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