The correlation between salivary EGF levels and recurrent oral manifestations in patients with Sjogren's syndrome

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Salivary epidermal growth factor(EGF) plays a role in healing of damaged oral mucosa. However, the kinetics of salivary EGF in Sjogren's Syndrome(SS) is not well-documented. The objective of this study was to assess changes in salivary EGF and the correlation between salivary EGF and the severity of oral manifestations in patients with SS. Consequently, in SS, not only saliva volume but salivary EGF output remain reduced throughout. Lower salivary EGF level is impairments of the saliva quality associate with recurrent oral manifestations.