Evaluation of bone quality based on the collagen cross-link formation for dental implant treatment.

人们已经认识到骨强度主要是由骨密度决定的。然而，已有研究报道骨质量是影响骨强度的重要因素，尤其是骨中胶原交联物的形成影响骨强度。在这项研究中，我关注骨胶原交联物的形成，以评价牙种植体治疗的骨质量。我们打算建立高效液相色谱法来测定骨骼中的吡啶酚和戊二胺，并检验种植体初始固定程度的相关性。

It has been recognized that bone strength is due primarily to bone density. However, it has been reported that bone quality is important factor for bone strength, especially the collagen cross-link formation in bone affect bone strength. In this study, I focused attention on the collagen cross-link formation in bone, to evaluate of bone quality for dental implant treatments. We planted to develop HPLC method to measure pyridinoline and pentosidine in bones, and to examine a correlate of the degree of initial fixation of implants.