Treatment strategy of oral mucosal disease that targeted thecontrol factor SOCS of JAK / STAT

针对JAK/STAT控制因子SOCS的口腔黏膜疾病治疗策略

• 批准号: 22791995
• 负责人: YOSHIGA Daigo
• 金额: $ 2.58万
• 依托单位: Kyushu Dental College (2011-2012)Kyushu University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791995/
• 关键词: SOCS,IL23,IL17,TLR; 炎症; 細菌; SOCS; IL23; IL6; TLR; 癌; IL-23; SOCS3; Th17; chronic inflammation; LPS; IFNg; JAK-STAT; 粘膜疾患; STAT; 白板症; 自然免疫

In this study, we carried out in immunologically-molecularbiological level functional analysis involvement of SOCS to activation of STAT byinflammatory cytokines and collapse of innate immunity via TLR for performing thetreatment of disease of the oral mucosa which is assumed to be caused by failure ofinnate immunity. In particular, it aimed to elucidate control mechanism (leukoplakia,lichen planus) of the oral mucosa diseases caused by cytokines and Th17, Treg, themechanism of pathogenesis in this application. I went to search for associated factorsin Th17, Treg oral cancer, lichen planus, in each oral mucosal disease fromleukoplakia. Upregulation IL6, TNFα, the IL-23 was observed in leukoplakia. ForTh17, Treg, expression RORγt, the Foxp3, was investigated by RT-PCR method ofexpression, GATA3 T-bet further respectively obvious difference was observed. I didnot grasp the obvious feature also localization of Th17. And it will be necessary toconsider further forward.

本研究从免疫学-分子生物学水平对SOCS参与炎症细胞因子激活STAT和TLR介导的天然免疫衰竭进行了功能分析，以治疗被认为是天然免疫衰竭引起的口腔黏膜疾病。特别是阐明细胞因子和Th 17、Treg在口腔黏膜疾病（白斑、扁平苔藓）中的控制机制及其发病机制。我去寻找相关因子在Th 17，Treg口腔癌，扁平苔藓，在每一个口腔粘膜疾病从白斑。IL-6、TNFα、IL-23在白斑中表达上调。用RT-PCR方法检测Th 17、Treg、RORγt、Foxp 3、GATA 3、T-bet的表达，进一步分别观察到明显差异。我没有抓住Th 17的明显特征和定位。有必要进一步考虑。

项目成果

Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages.

• DOI: 10.1371/journal.pone.0067906
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Muratsu D;Yoshiga D;Taketomi T;Onimura T;Seki Y;Matsumoto A;Nakamura S
• 通讯作者: Nakamura S

当科におけるエプーリス症例、特に骨セメント質形成性エプーリスの病理組織学 的検討

我科牙龈瘤尤其是骨水泥形成性牙龈瘤的组织病理学检查

• 发表时间: 2013
• 期刊: 九州歯科学会誌
• 作者: 野上晋之介;若林奈南子;宮本郁也;吉賀大午;金氏 毅;櫻井拓真;清宮弘康;山本哲彰;山内健介;高橋 哲.;吉賀大午・山下善弘・野上晋之介・山本哲彰・山内健介・金氏毅・櫻井拓真・田中達朗・森本泰宏・高橋哲;吉賀大午・石川文隆・山下善弘・山本哲彰・山内健介・野上晋之介・片岡良浩・櫻井拓真・森本泰宏・高橋哲;Yoshiga D;Yamamoto N;Kito S;Nogami S;古田絢也
• 通讯作者: 古田絢也

臼後部に発生した多形腺腫の１例

后磨牙区多形性腺瘤一例

• 发表时间: 2012
• 期刊: 日本口腔外科学会雑誌
• 作者: 吉賀大午;川野真太郎;小林家吉;鈴木華子;後藤雄一;中村誠司
• 通讯作者: 中村誠司

Clinical Comparison Between the Retromandibular Approach for Reduction and Fixation and Endoscope-Assisted Open Reduction and Internal Fixation for Mandibular Condyle Fractures

• DOI: 10.1097/scs.0b013e3182710393
• 发表时间: 2012-11-01
• 期刊: JOURNAL OF CRANIOFACIAL SURGERY
• 影响因子: 0.9
• 作者: Nogami, Shinnosuke;Takahashi, Tetsu;Yamashita, Yoshihiro
• 通讯作者: Yamashita, Yoshihiro

口腔粘膜組織欠損部修復におけるポリグリコール酸フェルトおよびフィブリン糊スプレーの使用経験.

使用聚乙醇酸毡和纤维蛋白胶喷雾修复口腔粘膜组织缺损的经验。

• 发表时间: 2013
• 期刊: 九州歯科学会誌
• 作者: 野上晋之介;若林奈南子;宮本郁也;吉賀大午;金氏 毅;櫻井拓真;清宮弘康;山本哲彰;山内健介;高橋 哲.
• 通讯作者: 高橋 哲.