The elucidation of the new osteoclast differentiation factor revealed from the pressure zone of periodontal ligament cells during tooth movement

牙齿移动过程中牙周膜细胞压力区揭示的新破骨细胞分化因子的阐明

• 批准号: 22792072
• 负责人: ARAI Chihiro
• 金额: $ 2.08万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792072/
• 关键词: 歯科矯正学; 歯の移動; Heat Shock Protein; Heat shock protein; 破骨細胞; 歯骨細胞

Gene expression of the pressure zone of periodontal ligament cells(PDL) during orthodontic tooth movement in vivo was observed. Heat shock protein A1A(HSPA1A) in the pressure zone of the PDL was higher during 6 h of tooth movement than that in the control group. These results strongly suggest that expression of HSPA1A in the PDL during the early stage of tooth movement is a critical factor for tissue reaction.

观察正畸牙移动过程中牙周膜细胞压力区基因表达的变化。热休克蛋白A1A（HSPA1A）在牙周膜压力区的牙齿移动6小时高于对照组。这些结果有力地表明，在牙齿移动的早期阶段，HSPA1A在PDL中的表达是组织反应的关键因素。

项目成果

HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats

• DOI: 10.1007/s00418-010-0737-3
• 发表时间: 2010-10-01
• 期刊: HISTOCHEMISTRY AND CELL BIOLOGY
• 影响因子: 2.3
• 作者: Arai, Chihiro;Nomura, Yoshiaki;Nakamura, Yoshiki
• 通讯作者: Nakamura, Yoshiki

Human periodontal ligament fibroblasts are the optimal source for induced pluripotent stem cells

人牙周膜成纤维细胞是诱导多能干细胞的最佳来源

• 发表时间: 2012
• 期刊: Histochem Cell Biol
• 影响因子: 2.3
• 作者: Nomura Y;Arai C;et al
• 通讯作者: et al

圧迫側歯根膜に発現する熱ショックタンパク質について

关于压缩牙周膜中表达的热休克蛋白

• 发表时间: 2010
• 作者: 新井千博;他
• 通讯作者: 他

Mechanism of active eruption of molars in adolescent rats

青春期大鼠磨牙主动萌出的机制

• DOI: 10.1093/ejo/cjq053
• 发表时间: 2011
• 期刊: Eur J Orthod
• 作者: Oikawa T;Nomura Y;Arai C;Noda K;Hanada N;Nakamura Y
• 通讯作者: Nakamura Y

Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement

• DOI: 10.1016/j.archoralbio.2010.11.010
• 发表时间: 2011-05-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Baba, Shunsuke;Kuroda, Noriyuki;Sato, Tetsuji
• 通讯作者: Sato, Tetsuji