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Investigation of the reaction mechanism of orotidine monophosphate decarboxylase using the distortion of the substrate

Investigation of the reaction mechanism of orotidine monophosphate decarboxylase using the distortion of the substrate
利用底物畸变研究乳清苷单磷酸脱羧酶的反应机制
批准号：
22770102
负责人：
FUJIHASHI Masahiro
金额：
$2.75万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22770102/
关键词：
X線結晶解析ODCase反応中間体構造基質構造の歪み酵素反応機構蛋白質X線結晶構造解析酵素基質複合体OMPDCOMPDCaseタンパク質X線結晶構造解析

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中文摘要
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英文摘要
Orotidine 5'-monophosphate decarboxylase(ODCase) accelerates the decarboxylation of orotidine 5'-monophosphate(OMP) to uridine 5'-monophosphate(UMP) by 17 orders of magnitude. We have determined several crystal structures with ligand analogues and performed computer simulations of the enzyme's short-lived intermediates. The results show that ODCase catalyzes the decarboxylation reaction utilizing both ground state destabilization and transition state stabilization.
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Elucidation of catalytic mechanism of two characteristic enzymes and its application based on crystal structures.
  • 批准号：
    24570130
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.49万
  • 财政年份：
    2012
  • 负责人：
    FUJIHASHI Masahiro
  • 依托单位：
    Kyoto University
Investigation of the structural change of orotidine 5'-monophosphate decarboxylase during the reaction and its catalytic mechanism
  • 批准号：
    20770081
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.83万
  • 财政年份：
    2008
  • 负责人：
    FUJIHASHI Masahiro
  • 依托单位：
    Kyoto University
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