A novel mechanism of act in nucleation by nebulin complex and its physiological role

肌原纤维是横纹肌的收缩器官，肌动蛋白丝是细胞形成和肌原纤维形成的必需条件。然而，骨骼肌肥大时肌原纤维的形成机制仍不清楚。本研究不仅揭示了Nebulin复合物在Z带形成肌动蛋白丝的新机制，而且揭示了该机制在生理性骨骼肌肥大中的重要作用。此外，这项研究表明，肌动蛋白丝形成的新机制可能参与心肌肥厚导致心力衰竭。

Actin filament is required for cell shape and formation of myofibril, which is contractile apparatus in striated muscle. However, the mechanism how myofibril is built during skeletal muscle hypertrophy remains obscure. In this study, not only it revealed a novel mechanism of actin filament formation at the Z-band by nebulin complex, but also the mechanism was essential for physiological skeletal muscle hypertrophy. Furthermore, this study suggested a possibility that the novel mechanism of actin filament formation might be involved in cardiac hypertrophy leading to heart failure.