A novel mechanism of act in nucleation by nebulin complex and its physiological role

肌动蛋白丝是细胞形状和肌原纤维形成所必需的，肌原纤维是横纹肌的收缩器官。然而，骨骼肌肥大过程中肌原纤维的形成机制尚不清楚。本研究不仅揭示了星云复合物在z带形成肌动蛋白丝的新机制，而且揭示了该机制是骨骼肌生理性肥大的必要机制。此外，本研究提示肌动蛋白丝形成的新机制可能参与心脏肥厚导致心力衰竭。

Actin filament is required for cell shape and formation of myofibril, which is contractile apparatus in striated muscle. However, the mechanism how myofibril is built during skeletal muscle hypertrophy remains obscure. In this study, not only it revealed a novel mechanism of actin filament formation at the Z-band by nebulin complex, but also the mechanism was essential for physiological skeletal muscle hypertrophy. Furthermore, this study suggested a possibility that the novel mechanism of actin filament formation might be involved in cardiac hypertrophy leading to heart failure.