Dynamic regulation of actin filament formation in the innervated skeletal muscle

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Striated muscle plays a fundamental role in maintenance of life depending on breathing, exercise and beating of heart by its contractile activity. However, the molecular mechanism how muscle hypertrophy is regulated during growth or pathological processes remains obscure. In denervated skeletal muscle and heart in vivo, this study showed that the N-WASP-mediated actin polymerization activity might be controlled by different mechanisms from that in intact skeletal muscle. In addition, the activity of N-WASP is indispensable for maintenance of heart function during cardiac hypertrophy by pressure-overload. Taken together, these results imply that the regulation of N-WASP activity may be controlled by unknown mechanisms during cardiac hypertrophy and is involved in the maintenance of physiological heart function.