Studies on the molecular mechanisms of left-right polarization of epithelial cells during left-right asymmetric development of Drosophila gut

许多双侧动物的身体表现出左右（LR）不对称。在脊椎动物中已经鉴定出许多参与左右轴形成的基因。然而，LR不对称器官形态产生的细胞机制仍然是未知的。本文研究了果蝇肠道LR的不对称性。我们的研究结果表明，Myo 31 DF和DE-Cad所需的LR偏向的细胞形状的形成和LR偏向的细胞形状是足以诱导定向LR不对称形态建成的果蝇肠道。

Many bilateral animals show left-right(LR) asymmetry in their body. Many genes involved in the left-right axis formation have been identified in vertebrates. However, the cellular mechanisms how LR asymmetric organ morphology is generated are still largely unknown. In this study, we studied the LR asymmetry of Drosophila gut. Our results suggest that Myo31DF and DE-Cad are required for the LR biased cell shape formation and LR biased cell shape is sufficient to induce the directional LR asymmetric morphogenesis of the Drosophila gut.