Preparation and evaluation of novel oral albumin formulation

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In this study, we aimed to develop a novel oral album in formulation with high permeability to the intestinal membrane by using a combination of site-directed mutagenesis and emulsion method. It was found that domain III mutants showed high permeability from the MDCK cells compared with other mutants. In addition, as for the nanoparticles prepared by using the multiple mutated albumins, the nanoparticles showed a good permeability compared with control. These results indicate the feasibility of preparation of recombinant albumin nanoparticles with high permeability to the intestinal membrane.