Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by Phosphoinositides

磷酸肌醇对髓鞘形成和葡萄糖代谢的调节 磷酸肌醇对髓鞘形成和葡萄糖代谢的调节

• 批准号: 22790055
• 负责人: TAKASUGA Shunsuke
• 金额: $ 2.58万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790055/
• 关键词: 脂質; 脳神経疾患; 糖尿病

We made tissue-specific phosphatidylinositol 3-phosphate 5-kinase (PIPKIII) knockout mice for analyses of myelination in central nervous system and glucose metabolism in muscle. We indicated that essential roles of PIPKIII in oligodendrocytes. And we also found that PIPKIII is a negative regulator of insulin signaling in skeletal muscle.

我们制作了组织特异性磷脂酰肌醇3-磷酸5-激酶（PIPKIII）基因敲除小鼠，用于分析中枢神经系统的髓鞘形成和肌肉中的葡萄糖代谢。我们指出PIPKIII在少突胶质细胞中的重要作用。我们还发现PIPKIII是骨骼肌中胰岛素信号的负调节剂。

项目成果

Physiological function of phosphatidylinositol -3, 5-bisphosphate in vivo

磷脂酰肌醇-3,5-二磷酸的体内生理功能

• 发表时间: 2010
• 作者: Takasuga S;Sasaki J;Suzuki A;Sasaki T.
• 通讯作者: Sasaki T.

3' phosphatase activity toward PI(3,4)P2 by voltage-sensing phosphatase, VSP

电压感应磷酸酶 (VSP) 对 PI(3,4)P2 的 3 磷酸酶活性

• 发表时间: 2012
• 期刊: Proc. Natl. Acad. Sci. U. S. A
• 作者: Kurokawa T;Takasuga S;Sakata S;Yamaguchi S;Horie S;Homma KJ;Sasaki T & Okamura Y
• 通讯作者: Sasaki T & Okamura Y

Novel acyl-coenzyme A: monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion

• DOI: 10.1194/jlr.m002584
• 发表时间: 2010-06-01
• 期刊: JOURNAL OF LIPID RESEARCH
• 影响因子: 6.5
• 作者: Hiramine, Yasushi;Emoto, Hisayo;Hiramatsu, Ryuji
• 通讯作者: Hiramatsu, Ryuji

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

• DOI: 10.1038/nature09023
• 发表时间: 2010-05-27
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Sasaki, Junko;Kofuji, Satoshi;Sasaki, Takehiko
• 通讯作者: Sasaki, Takehiko