Role of arachidonic acid cascade on neurodegeneration in Niemann-Pick desease type C.

本研究旨在探讨花生四烯酸在鼻咽癌中的代谢。此外，我们还研究了鞘脂在NPC中积累对花生四烯酸代谢的影响。结果表明：1）cPLA 2 α依赖的花生四烯酸代谢在鼻咽癌细胞的细胞毒作用和ROS形成中起重要作用; 2）SM和LacCer是cPLA 2 α的直接调节因子。

In this study, we investigated the metabolism of arachidonic acid in NPC. In addition, we examined the effect of sphingolipids accumulated in NPC on the metabolisms of arachidonic acid. We showed that 1) cPLA2α-dependent arachidonic acid metabolism plays important roles in the cytotoxicity and the ROS formation in NPC cells, 2) SM and LacCer are direct regulators of cPLA2α.