The role of serine protease granzyme on the induction of itch in atopic dermatitis
The role of serine protease granzyme on the induction of itch in atopic dermatitis
批准号:
22790063
负责人:
ANDOH Tsugunobu
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The precious mechanisms of itch in atopic dermatitis are unclear. Since T cells infiltrate into the skin with atopic dermatitis and the proteases are also involved in the severe itch, we focused proteases produced by T cells for demonstrating the itch mechanisms in the dermatitis. It was demonstrated that granzyme A, which is one of 11 subtypes of granzymes, elicited itch through the activation of proteinase-activated receptor 2
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どうしても止めたい「かゆみ」。でも「かゆみ」ってどうやって起こるの?
我真的很想停止这种痒。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsugunobu Andoh, Qun Zhang, Tsugunobu Andoh, Yoshikazu Gotoh, 安東嗣修]
通讯作者:
安東嗣修
動物モデルと痒みの評価法
动物模型及瘙痒评价方法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[羽座沙都美, 他, Hirata M, Matsumoto C, 後藤義一, 高木梨名, 青木崇史, Tsugunobu Andoh, 門間奈津希, 安東嗣修, Hirata M, 安東嗣修, Matsumoto C, 清水和, 安東嗣修]
通讯作者:
安東嗣修
アレルギー性疾患のバイオマーカーおよびその利用
过敏性疾病的生物标志物及其用途
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
「かゆみの動物モデルの作製と評価方法」
《瘙痒动物模型的制作及评价方法》
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kobayashi M, Matsumoto C, Hirata M, Tominari T, Inada M and Miyaura C, 安東嗣修]
通讯作者:
安東嗣修
Proteases and itch
蛋白酶和瘙痒
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Tsugunobu Andoh, 他]
通讯作者:
他
共 26 条
Elucidation of mechanisms of itching mediated by basophils in atopic dermatitis and application to clinical treatment
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批准号:20K07081
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2020
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负责人:ANDOH Tsugunobu
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依托单位:
Identification of itch mediators using clinical samples of dialysis patients and application to clinical treatment
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批准号:16K15337
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2016
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负责人:ANDOH Tsugunobu
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依托单位:
Role of skin aspartic protease SASPase on the induction of itch in atopic dermatitis
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批准号:25460717
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:ANDOH Tsugunobu
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依托单位:
Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch
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批准号:19790051
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.39万
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财政年份:2007
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负责人:ANDOH Tsugunobu
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依托单位:
海外基金