Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch
Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch
批准号:
19790051
负责人:
ANDOH Tsugunobu
金额:
$2.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In addition to the involvement of proteinases on the induction of itch in atopic dermatitis, the mechanisms were also investigated. This study demonstrated that serine proteinases, such as tryptase, and proteinase-activated receptor-2 (PAR_2) played an important role on the induction of itch in atopic dermatitis. In addition to keratinocytes, PAR_2 is expressed on primary afferents. Thus, PAR_2-expressed primary afferent is important on the transmission of itch in atopic dermatitis.
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アレルギー性疾患のバイオマーカーおよびその利用
过敏性疾病的生物标志物及其用途
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[]
通讯作者:
皮膚における痒みのメカニズム
皮肤瘙痒的机制
DOI:
--
发表时间:
2022
期刊:
影响因子:
--
作者:
[加藤 千智, 大森 貴俊, 中西 和也, 村川 由佳, 三宅 歩, 安東嗣修]
通讯作者:
安東嗣修
マウスにおける花粉誘発アレルギー性眼掻痒発生へのセリンプロテアーゼの関与
丝氨酸蛋白酶参与花粉引起的小鼠过敏性眼部瘙痒的发生
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Tanimura S., Uchiyama A., Watanabe K., Yasunaga M., Inada Y., Kawabata T., Iwashita K., Noda S., Ozaki K., Kohno M., 本間あずさ]
通讯作者:
本間あずさ
DOI:
10.1254/jphs.08332fp
发表时间:
2009-03-01
期刊:
JOURNAL OF PHARMACOLOGICAL SCIENCES
影响因子:
3.5
作者:
[Tsujii, Kenichiro, Andoh, Tsugunobu, Kuraishi, Yasushi]
通讯作者:
Kuraishi, Yasushi
痒みにおけるケラチノサイトの役割
角质形成细胞在瘙痒中的作用
DOI:
--
发表时间:
2009
期刊:
アレルギーの臨床 Vol.29
影响因子:
--
作者:
[塩田倫史, 韓 峰, 山本由似, 森口茂樹, 山口芳正, 日野正孝, 福永浩司(口演), 安東嗣修]
通讯作者:
安東嗣修
共 25 条
Elucidation of mechanisms of itching mediated by basophils in atopic dermatitis and application to clinical treatment
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批准号:20K07081
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2020
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负责人:ANDOH Tsugunobu
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依托单位:
Identification of itch mediators using clinical samples of dialysis patients and application to clinical treatment
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批准号:16K15337
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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财政年份:2016
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负责人:ANDOH Tsugunobu
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依托单位:
Role of skin aspartic protease SASPase on the induction of itch in atopic dermatitis
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批准号:25460717
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2013
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负责人:ANDOH Tsugunobu
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依托单位:
The role of serine protease granzyme on the induction of itch in atopic dermatitis
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批准号:22790063
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.41万
-
财政年份:2010
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负责人:ANDOH Tsugunobu
-
依托单位:
海外基金