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Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch

Identification of cutaneous serine proteinases related the induction of itch in atopic dermatitis and the mechanisms of itch
特应性皮炎瘙痒诱发相关皮肤丝氨酸蛋白酶的鉴定及瘙痒机制
批准号:
19790051
负责人:
ANDOH Tsugunobu
金额:
$2.39万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
In addition to the involvement of proteinases on the induction of itch in atopic dermatitis, the mechanisms were also investigated. This study demonstrated that serine proteinases, such as tryptase, and proteinase-activated receptor-2 (PAR_2) played an important role on the induction of itch in atopic dermatitis. In addition to keratinocytes, PAR_2 is expressed on primary afferents. Thus, PAR_2-expressed primary afferent is important on the transmission of itch in atopic dermatitis.
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会议论文
アレルギー性疾患のバイオマーカーおよびその利用
过敏性疾病的生物标志物及其用途
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: []
通讯作者:
DOI: --
发表时间: 2022
期刊:
影响因子: --
作者: [加藤 千智, 大森 貴俊, 中西 和也, 村川 由佳, 三宅 歩, 安東嗣修]
通讯作者: 安東嗣修
マウスにおける花粉誘発アレルギー性眼掻痒発生へのセリンプロテアーゼの関与
丝氨酸蛋白酶参与花粉引起的小鼠过敏性眼部瘙痒的发生
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Tanimura S., Uchiyama A., Watanabe K., Yasunaga M., Inada Y., Kawabata T., Iwashita K., Noda S., Ozaki K., Kohno M., 本間あずさ]
通讯作者: 本間あずさ
DOI: 10.1254/jphs.08332fp
发表时间: 2009-03-01
期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
影响因子: 3.5
作者: [Tsujii, Kenichiro, Andoh, Tsugunobu, Kuraishi, Yasushi]
通讯作者: Kuraishi, Yasushi
25
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