Efficacy of combination treatment with arsenic trioxide and all-trans retinoic acid on acute promyelocytic leukemia therapy

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In this study, we performed basic experiments to determine whether the treatment with all-trans retinoic acid(ATRA) plus arsenic trioxide(ATO) in combination is beneficial in Acute Promyelocytic Leukemia(APL) therapy than that with a single agent. In order to determine the ATRA-induced differentiation is augmented by the addition of ATO, we compared the surface expression of CD 11 b in human leukemia HL60 cells incubated with ATRA, ATO, or ATRA plus ATO. The result indicates that HL60 cells treated with ATO plus ATRA show further differentiation than those treated with ATRA alone, suggesting that cotreatment of ATO plus ATRA is more effective than the treatment with a single agent in enhancing the differentiation of HL60 cells.