Clinical pharmacokinetic trials in pediatric patients based on a peak-and-trough sampling design
基于峰谷采样设计的儿科患者临床药代动力学试验
基本信息
- 批准号:22790149
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The area under the concentration. time curve(AUC) and/or oral clearance(CL/F) of drugs is a key pharmacokinetic parameter to evaluate drug exposure in patients. In the present study, we conducted a clinical trial to evaluate the pharmacokinetics of bosentan in Japanese pediatric patients. Plasma samples were taken twice at two time points corresponding to the peak concentration(C_<peak>) and trough concentration(C_<trough>) following repetitive oral drug administration to the petients. A large interindividual variability was observed in plasma concentrations of bosentan, and the weight-normalized values of CL/F were correlated negatively with age. We confirmed that the peak-and-trough sampling design is promising for the clinical repeated-dose pharmacokinetic trial for drugs.
浓度下的面积。药物的时间曲线(AUC)和/或口服清除率(CL/F)是评价患者药物暴露的关键药代动力学参数。在本研究中,我们进行了一项临床试验,以评估波生坦在日本儿科患者中的药代动力学。患者反复口服药物后,分别在血药浓度峰(C_<峰>)和血药浓度谷(C_<谷>)对应的两个时间点取两次血浆样本。波生坦血浆浓度存在较大的个体间差异,体重标准化后的CL/F值与年龄呈负相关。我们证实了峰谷抽样设计在药物的临床重复剂量药代动力学试验中是有希望的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells
- DOI:10.1002/bdd.755
- 发表时间:2011-07-01
- 期刊:
- 影响因子:2.1
- 作者:Horie, Asuka;Sakata, Jumpei;Hashimoto, Yukiya
- 通讯作者:Hashimoto, Yukiya
Effect of genetic polymorphisms of nucleoside and efflux transporters on bioavailability of mizoribine
核苷和外排转运蛋白基因多态性对咪唑立宾生物利用度的影响
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Fukao M.;Ishida K.;Taguchi M.;Matsukura H.;Miyawaki T.;and Hashimoto Y.
- 通讯作者:and Hashimoto Y.
腸上皮LS180細胞を用いたプロカインアミドの膜輸送特性解析
使用肠上皮LS180细胞分析普鲁卡因酰胺的膜转运特性
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:石田和也,真砂美希,坂田淳平,鷹合麻里,堀江明日佳,伊藤俊和,田口雅登;橋本征也
- 通讯作者:橋本征也
Pharmacokinetics of bosentan in routinely treated Japanese pediatric patients with pulmonary arterial hypertension
波生坦在常规治疗的日本肺动脉高压儿科患者中的药代动力学
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Taguchi M.;Ichida F.;Hirono K.;Miyawaki T.;Yoshimura N.;Nakamura T.;Akita C.;Nakayama T.;Saji T.;Kato Y.;Horiuchi I.;and Hashimoto Y.
- 通讯作者:and Hashimoto Y.
腎上皮LLC-PK1および腸上皮LS180細胞におけるプロカインアミドの膜輸送機構解析
普鲁卡因酰胺在肾上皮LLC-PK1和肠上皮LS180细胞中的膜转运机制分析
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:舟橋達也;田邊知孝;牧純;宮本勝城;辻坊裕;山本重雄;真砂美希,坂田淳平,西條早紀,鷹合麻里,堀江明日佳,伊藤俊和,石田和也,田口雅登,橋本征也
- 通讯作者:真砂美希,坂田淳平,西條早紀,鷹合麻里,堀江明日佳,伊藤俊和,石田和也,田口雅登,橋本征也
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TAGUCHI Masato其他文献
Three-Dimensional Hypersonic Aeroheating Computations Associated with Cross-Flow Jet Interactions
与错流射流相互作用相关的三维高超声速气动加热计算
- DOI:
10.2322/astj.jsass-d-20-00015 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
KITAMURA Keiichi;HASE Naoya;TAGUCHI Masato;MORI Koichi - 通讯作者:
MORI Koichi
TAGUCHI Masato的其他文献
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{{ truncateString('TAGUCHI Masato', 18)}}的其他基金
Precision and accuracy of clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance
应用峰谷采样设计估计口腔清除率的临床重复剂量药代动力学试验的精确度和准确性
- 批准号:
20790130 - 财政年份:2008
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
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