Development of Immunomodulatory Cytokine mutants

I型干扰素（ifn）是一种多效性细胞因子，可引起抗病毒和抗增殖反应。在这项研究中，我们试图创造一个具有更高抗病毒活性的IFN突变体。首先，我们构建了一个展示IFN突变体的噬菌体文库。对噬菌体文库进行几轮筛选，以浓缩与IFN受体高亲和力的突变IFN。结果表明，与野生型IFN相比，一些候选物表现出更高的亲和力和抗病毒活性。

Type I interferons(IFNs) are pleiotropic cytokines that elicit antiviral and antiproliferative responses. In this study, we attempted to create a mutant IFN with higher anti-viral activity. At first, we constructed a phage library displaying IFN mutants. The phage library was performed to several rounds of panning to concentrate mutatnt IFN with high affinity to IFN receptor. As the results, some candidates exhibited higher affinity and anti-viral activity compare to wild type IFN.