Analysis of Dlg1 function in the development of the cardiac neural crest cells.

Dlg1基因靶向小鼠表现出包括流出道分离缺损和室间隔缺损在内的先天性心脏缺陷。心脏神经嵴细胞的分布没有表现出延迟迁移。另一方面，Corti器官、肠、输尿管和胸骨的伸长不足。由于最近报道的会聚延伸过程中需要在这些组织的伸长和流出道的发展，Dlg1可能参与器官发生通过其在会聚延伸的作用。

Dlg1 gene targeted mice exhibit congenital heart defects including outflow tract separation defect and ventricular septal defect. Distribution of cardiac neural crest cells did not exhibit retarded migration. On the other hand, elongation of organ of Corti, intestine, ureter and sternum was insufficient in these mice. As the convergent extension process was recently reported to be needed in the elongation of these tissues and in the outflow tract development, Dlg1 may be involved in the organogenesis through its role in the convergent extension.