Analysis of Dlg1 function in the development of the cardiac neural crest cells.

Dlg1基因靶向小鼠表现出先天性心脏缺陷，包括流出道分离缺陷和室间隔缺陷。心脏神经嵴细胞的分布没有表现出迁移迟缓。另一方面，小鼠Corti、肠、输尿管和胸骨的伸长不足。最近有报道称，这些组织的伸长和流出道的发育都需要趋同伸展过程，Dlg1可能通过其在趋同伸展中的作用参与了器官发生。

Dlg1 gene targeted mice exhibit congenital heart defects including outflow tract separation defect and ventricular septal defect. Distribution of cardiac neural crest cells did not exhibit retarded migration. On the other hand, elongation of organ of Corti, intestine, ureter and sternum was insufficient in these mice. As the convergent extension process was recently reported to be needed in the elongation of these tissues and in the outflow tract development, Dlg1 may be involved in the organogenesis through its role in the convergent extension.