The effect of stress-induced sympathetic activation on ovarian function and morphology

在大鼠中研究了交感神经过度活跃在应激诱导的卵巢功能障碍中的作用。急性应激（伤害性皮肤刺激）通过激活卵巢上级神经降低卵巢雌二醇分泌率。激活卵巢上级神经导致雌二醇分泌减少是由于抑制睾酮转化为雌二醇所致。慢性应激导致交感神经过度激活，导致卵巢组织发生形态学变化（囊性卵泡数量增加，黄体数量减少），表明排卵功能障碍。

Involvement of sympathetic nerve hyperactivity in stress-induced ovarian dysfunction was examined in rats. Acute stress(nociceptive cutaneous stimulation) reduced the ovarian estradiol secretion rate via activation of the superior ovarian nerve. The reduction of estradiol secretion by superior ovarian nerve activation was caused by inhibition of testosterone conversion into estradiol. Chronic stress, which caused sympathetic nerve hyperactivation, produced morphological changes in the ovarian tissues(increase in the number of cystic follicles and decrease in the number of corpus luteum), suggesting an ovulatory dysfunction.