Antipsychotic potential of antioxidative agents in animal model for schizophrenia
Antipsychotic potential of antioxidative agents in animal model for schizophrenia
批准号:
22790245
负责人:
MIZUNO Makoto
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
我们建立了精神分裂症模型,并检验了抗氧化剂的抗精神病作用。服用抗氧化剂一周显著改善了精神分裂症模型大鼠的社会交往缺陷和脉冲前抑制。这些结果提示抗氧化剂可能是一类新的精神分裂症抗精神病药物。
英文摘要
We established the model for schizophrenia and examined the antipsychotic actions of antioxidants. Administration of antioxidants for a week significantly ameliorated deficits of social interaction and prepulse inhibition of the schizophrenia model rats. These results suggest that antioxidants may be a new class of antipsychotic drugs for schizophrenia.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Nawa H Pallidal Hyperdopaminergic Innervation Underlying D2 Receptor-Dependent Behavioral Deficits in the Schizophrenia Animal Model Established by EGF
Nawa H EGF 建立的精神分裂症动物模型中 D2 受体依赖性行为缺陷背后的苍白球多巴胺能神经支配
DOI:
--
发表时间:
2011
期刊:
PLoS One
影响因子:
3.7
作者:
[Sotoyama H, Zheng Y, Iwakura Y, Mizuno M, Aizawa M, Shcherbakova K, Wang R, Namba H]
通讯作者:
Namba H
Effects of antioxidative agents on behavioral impairments in schizophrenia models
抗氧化剂对精神分裂症模型行为障碍的影响
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[水野誠, 森田影介, 那波宏之]
通讯作者:
那波宏之
DOI:
10.1016/j.neures.2010.06.008
发表时间:
2010-10-01
期刊:
NEUROSCIENCE RESEARCH
影响因子:
2.9
作者:
[Qi, Sihua, Mizuno, Makoto, Takei, Nobuyuki]
通讯作者:
Takei, Nobuyuki
The anthraquinone derivative emodin attenuates methamphetamine-induced hyperlocomotion and startle response in rats
蒽醌衍生物大黄素可减弱甲基苯丙胺引起的大鼠过度运动和惊吓反应
DOI:
--
发表时间:
2010
期刊:
Pharmacol Biochem Behav
影响因子:
--
作者:
[Mizuno M, Kawamura H, Ishizuka Y, Sotoyama H, Nawa H]
通讯作者:
Nawa H
Antipsychotic potentical of quinazoline ErbB1 inhibitors in a schizophrenia model established with neonatal hippocampal lesioning
喹唑啉 ErbB1 抑制剂在新生儿海马损伤精神分裂症模型中的抗精神病作用
DOI:
--
发表时间:
2010
期刊:
J Pharmacol Sci
影响因子:
3.5
作者:
[Mizuno M, Shibuya M, Zheng Y, Sotoyama H, Eda Y, Iwakura Y, Kato T, Takasu K, Nawa H]
通讯作者:
Nawa H
共 6 条
The Study on CRM Approaches Accounting for Dynamic Change of CustomerBehavior
-
批准号:22530463
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.33万
-
财政年份:2010
-
负责人:MIZUNO Makoto
-
依托单位:
Regulation of dopaminergic neuron development by trophic factor and neurofunction disorder
-
批准号:20790203
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2008
-
负责人:MIZUNO Makoto
-
依托单位:
The Study on Social Interaction among Consumers and Dynamic Change of Preferences
-
批准号:19530379
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.41万
-
财政年份:2007
-
负责人:MIZUNO Makoto
-
依托单位:
Study on Formation and Change of Consumer Preference
-
批准号:16530277
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2004
-
负责人:MIZUNO Makoto
-
依托单位:
海外基金