Spatio-temporal analysis of intracellularcalcium oscillation in the pulmonary vein myocardium

肺静脉心肌细胞内钙振荡的时空分析

• 批准号: 22790262
• 负责人: NAMEKATA Iyuki
• 金额: $ 2.5万
• 依托单位: Toho University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790262/
• 关键词: 薬理学; 肺静脈心筋; カルシウムイメージング; 自動能; 心房細動; カルシウム; イメージング

We assessed the electrophysiological properties of pulmonary vein myocardium and analyzed its arrhythmogenic activity. Some of the pulmonary vein cardiomyocytes, but not atrial cardiomyocytes, showed sustained spontaneous Ca2+transients. But morphology and the sarcoplasmic reticulum content of pulmonary vein cardiomyocytes were the same as those of atrial myocytes. The pulmonary vein myocardium had a less negative resting membrane potential and lower density of inwardly rectifying potassium current than atrial. These results suggest that the lower density of repolarizing currents in pulmonary vein cardiomyocytes appears to play a permissive role for depolarization induced by elevation of intracellular Ca2+.

观察肺静脉心肌电生理特性，分析其致心律失常活性。一些肺静脉心肌细胞，而不是心房心肌细胞，显示持续的自发Ca2+瞬态。肺静脉心肌细胞的形态和肌浆网含量与心房肌细胞相同。肺静脉心肌的静息负膜电位和向内整流钾电流密度均低于心房。这些结果表明，肺静脉心肌细胞中较低密度的复极电流似乎对细胞内Ca2+升高诱导的去极化起许可作用。

项目成果

Electropharmacological properties of the pulmonary vein myocardium.

肺静脉心肌的电药理学特性。

• 发表时间: 2011
• 期刊: Current Topics in Pharmacology.
• 作者: Hikaru Tanaka;Yayoi Tsuneoka;Iyuki Namekata.
• 通讯作者: Iyuki Namekata.

肺静脈心筋の電気的自発活動の発生機序:心房細動治療標的としての可能性

肺静脉心肌自发电活动机制：作为心房颤动治疗靶点的可能性

• 发表时间: 2012
• 作者: Tadayuki Takashima;Hiroko Nagata;Hideki Ishii;Ryosuke Ijuin;Takahiro Nakae;Masaaki Tanaka;Yoshihito Shigihara;Suzuka Ataka;Hisashi Doi;Yasuhiro Wada;Masaaki Suzuki;Kazuya Maeda;Hiroyuki Kusuhara;Yuichi Sugiyama;Yasuyoshi Watanabe;河原圭;行方衣由紀;恒岡弥生;白川亮;行方衣由紀;行方衣由紀
• 通讯作者: 行方衣由紀

Membrane potential and intracellular calcium oscillations in the guinea-pig and rat pulmonary vein myocardium.

豚鼠和大鼠肺静脉心肌的膜电位和细胞内钙振荡。

• 发表时间: 2011
• 作者: Tadayuki Takashima;Hiroko Nagata;Hideki Ishii;Ryosuke Ijuin;Takahiro Nakae;Masaaki Tanaka;Yoshihito Shigihara;Suzuka Ataka;Hisashi Doi;Yasuhiro Wada;Masaaki Suzuki;Kazuya Maeda;Hiroyuki Kusuhara;Yuichi Sugiyama;Yasuyoshi Watanabe;河原圭;行方衣由紀;恒岡弥生;白川亮;行方衣由紀;行方衣由紀;濱口正悟;恒岡弥生;岡貴之;大槻篤史;Iyuki Namekata
• 通讯作者: Iyuki Namekata

こどもの心臓からおとなの心臓へ-心筋興奮収縮機構の発達変化-

从小孩的心脏到成人的心脏——心肌兴奋和收缩机制的发育变化——

• 发表时间: 2011
• 作者: Tadayuki Takashima;Hiroko Nagata;Hideki Ishii;Ryosuke Ijuin;Takahiro Nakae;Masaaki Tanaka;Yoshihito Shigihara;Suzuka Ataka;Hisashi Doi;Yasuhiro Wada;Masaaki Suzuki;Kazuya Maeda;Hiroyuki Kusuhara;Yuichi Sugiyama;Yasuyoshi Watanabe;河原圭;行方衣由紀;恒岡弥生;白川亮;行方衣由紀;行方衣由紀;濱口正悟;恒岡弥生;岡貴之;大槻篤史;Iyuki Namekata;Iyuki Namekata;恒岡弥生;恒岡弥生;疋田康;疋田康;田中光
• 通讯作者: 田中光

Electrophysiological Effects of the Class Ic Antiarrhythmic Drug Pilsicainide on the Guinea-Pig Pulmonary Vein Myocardium

Ic类抗心律失常药物匹西卡尼对豚鼠肺静脉心肌的电生理作用

• DOI: 10.1254/jphs.12022fp
• 发表时间: 2012
• 期刊: Journal of Pharmacological Sciences
• 影响因子: 3.5
• 作者: Takahara A;Takeda K;Tsuneoka Y;Hagiwara M;Namekata I;Tanaka H
• 通讯作者: Tanaka H