Syntheses of PET probes of Chinese medicinal plants, and those pharmacokinetics analysis
Syntheses of PET probes of Chinese medicinal plants, and those pharmacokinetics analysis
批准号:
22790265
负责人:
ISHII Hideki
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
β-谷甾醇、6-姜黄素、姜黄素、白菊内酯、吴茱萸内酯等已用于正电子发射光谱探针前体物或标准品的合成,用有机溶剂提取半夏、生姜、姜黄、白藜芦醇和吴茱萸中的相应粉末后,用柱层析法分离得到。成功地合成了相应的β-谷甾醇和姜黄素的探针前体(硼酸酯)。
英文摘要
β-Sitosterol, 6-gingerol, curcumin, parthenolide, and evodiamine, which have used for the synthesis of PET-probe precursors or standard samples, have isolated using column chromatography after the extraction with organic solvents of corresponding powders from the commercially available Chinese medicinal plants : Pinellia tuber, Zingiber siccatum, Curcuma longa, Feverfew, and Evodiae fructus. Corresponding^<11> C-PET probe precursors(boronic acid esters) ofβ-sitosterol and curcumin have successfully synthesized.
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