Relationship between renal function and composition of coronary arterial atherosclerotic plaques

肾功能与冠状动脉粥样硬化斑块成分的关系

• 批准号: 22790699
• 负责人: ISHII Hideki
• 金额: $ 2.58万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790699/
• 关键词: 循環器; 冠動脈; 腎障害; 血管内超音波; 冠動脈形成術; 動脈硬化; 慢性腎疾患; 心筋障害

The present study was conducted to identify any relationship between estimated glomerular filtration rate(eGFR) and coronary plaque characteristics using integrated backscatter intravascular ultrasound(IB-IVUS) which can detect coronary plaque composition. eGFR significantly correlated with both parameters(r=-0. 68, p<0. 001 and r=0. 69, p<0. 001, respectively). In conclusion, lower eGFR levels are associated with higher lipid and lower fibrous contents, contributing to coronary plaque vulnerability.

本研究旨在使用可检测冠状动脉斑块成分的背向散射血管内超声（IB-IVUS）确定估计肾小球滤过率（eGFR）与冠状动脉斑块特征之间的任何关系。eGFR与两个参数均显著相关（r=-0. 68，p<0. 001，r=0。69，p<0. 001）。总之，较低的eGFR水平与较高的脂质和较低的纤维含量相关，有助于冠状动脉斑块的脆弱性。

项目成果

Impact of High-Density Lipoprotein Cholesterol Levels on Peri-Procedural Myocardial Injury Post Elective Stent Implantation in Patients with Chronic Statin Treatment

高密度脂蛋白胆固醇水平对慢性他汀类药物治疗患者择期支架植入后围手术期心肌损伤的影响

• 发表时间: 2011
• 作者: Okada T;Yoshikawa D;Ishii H;Sato B;Kurebayashi N;Ando H;Hayakawa S;Hayashi M;Murohara T
• 通讯作者: Murohara T

Impact of diabetes and glycaemic control on peripheral artery disease in Japanese patients with end-stage renal disease. Long-term follow-up study from beginning of haemodialysis

糖尿病和血糖控制对日本终末期肾病患者外周动脉疾病的影响。

• 期刊: Diabetologia
• 影响因子: 8.2
• 作者: Ishii H;Kumada Y;Takahashi H;Toriyama T;Aoyama T;Tanaka M;Yoshikawa D;Hayashi M;Kasuga H;Yasuda Y;Maruyama S;Matsubara T;Matsuo S;Murohara T.
• 通讯作者: Murohara T.

Tissue Characterization of Coronary Plaque in Patients With Renal Dysfunction

肾功能不全患者冠状动脉斑块的组织特征

• 发表时间: 2011
• 作者: Hayano S;Ishii H;Ichimiya S;Kanashiro M;Watanabe J;Yoshikawa D;Matsubara T;Murohara T
• 通讯作者: Murohara T

Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque

• DOI: 10.1253/circj.cj-11-0019
• 发表时间: 2011-08-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Kurebayashi, Nobutake;Yoshikawa, Daiji;Murohara, Toyoaki
• 通讯作者: Murohara, Toyoaki