The contribution of Delta signaling regulated by γ-secretase on the differentiation of peripheral CD4 T cells

我研究了Notch或Delta信号在不同培养条件下对Th分化的贡献。虽然Notch/Delta信号对Th1、Th2和Treg的分化没有影响，但在中性条件下，Notch信号对Th17的分化有轻微影响。由于在Th17培养条件下未检测到这种效应，因此该结果表明Notch信号对Th17的分化与通常的Th17培养条件有所不同。

I examined the contribution of Notch or Delta signaling to Th differentiation under various culture conditions. Although there was no effect of Notch/Delta signaling on Th1, Th2 and Treg differetiation, a slight effect of Notch signalingon Th17 differentiation under neutral condition was observed. Since this effect was notdetected in the Th17 culture condition, this result suggests that Th17 differentiation by Notch signaling was something different from that in the usual Th17 culture condition.