The contribution of Delta signaling regulated by γ-secretase on the differentiation of peripheral CD4 T cells

γ-分泌酶调控的Delta信号对外周CD4 T细胞分化的贡献

• 批准号: 22790278
• 负责人: NAGASE Hisashi
• 金额: $ 2.25万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790278/
• 关键词: Notch; Delta; シグナル伝達; γ-セクレターゼ; Th細胞

I examined the contribution of Notch or Delta signaling to Th differentiation under various culture conditions. Although there was no effect of Notch/Delta signaling on Th1, Th2 and Treg differetiation, a slight effect of Notch signalingon Th17 differentiation under neutral condition was observed. Since this effect was notdetected in the Th17 culture condition, this result suggests that Th17 differentiation by Notch signaling was something different from that in the usual Th17 culture condition.

我研究了Notch或Delta信号在不同培养条件下对Th分化的贡献。在中性条件下，虽然Notch/Delta信号对Th1、Th2和Treg的分化没有影响，但对Th17的分化有轻微的影响。由于在Th17培养条件下没有检测到这种影响，这一结果表明通过Notch信号诱导的Th17分化不同于通常的Th17培养条件。

项目成果

Neural Stem Cells and Therapy

神经干细胞和治疗

• 发表时间: 2011
• 作者: Horisawa,K.;Yanagawa;H
• 通讯作者: H

Amyloids : composition, functions, and pathology

• 发表时间: 2012
• 作者: Irene P. Halcheck;Nancy R. Vernon

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.

• DOI: 10.1016/j.gene.2010.11.014
• 发表时间: 2011-04
• 期刊: Gene
• 影响因子: 3.5
• 作者: Takeshi Ohkawara;H. Nagase;C. Koh;K. Nakayama

γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein. Neural Stem Cells & Therapy

γ-分泌酶调节的信号传导机制：Notch 和淀粉样前体蛋白。神经干细胞和治疗。

• 发表时间: 2012
• 作者: Nakayama K;Nagase H;Koh CS;Ohkawara T.
• 通讯作者: Ohkawara T.

Notch, APP, and Alzheimer's Disease

Notch、APP 和阿尔茨海默病

• DOI: 10.2174/2211556011201020155
• 发表时间: 2012
• 期刊: Current Psychopharmacology.
• 作者: Nakayama K;Nagase H;Koh CS;Ohkawara T. γ-Secretase-Regulated Signaling
• 通讯作者: Ohkawara T. γ-Secretase-Regulated Signaling