In depth characterisation of the gamma delta T cell immune synapse

该项目旨在全面描述伽马三角洲T细胞的激活原理。这些细胞在脊椎动物的免疫和发育中扮演着一个未被充分研究但却是核心的角色。缺少的一块拼图是，伽马德尔塔T细胞如何感知压力，以及这个信号如何导致激活。预期结果包括产生免疫学和结构生物学的基础知识。这项建议使用了包括冷冻电子显微镜和单分子成像在内的高技能技术，并为研究生带来了辅助好处。预期的结果包括出版有影响力的出版物，在澳大利亚建立一批关键的专业知识，并促进与澳大利亚在震中的国际合作。

This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.