Synaptic formation and maturation regulated by membrane trafficking leading to higher function of the nervous system

Rab家族小G蛋白在调节囊泡运输中充当分子开关。在这项研究中，我们专注于Rab 3A，Rab 13及其相关蛋白在突触形成和成熟中的作用和作用方式，从而导致神经系统的更高功能。对于Rab 3A，我们发现缺乏Rab 3A相关蛋白Rabconnectin的小鼠表现出神经元功能障碍，可能是由于突触组织的畸形。我们还发现Rab 13-JRAB系统在PC 12细胞突起延伸过程中调节肌动蛋白细胞骨架的重组。我们的研究结果表明，该系统可以同时协调囊泡运输和肌动蛋白细胞骨架重组突触形成成熟。

Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in synaptic formation and maturation, leading to higher function of the nervous system. As to Rab3A, we found the mice lacking Rabconnectin, the Rab3A-related protein, exhibit neuronal dysfunction, probably because of misformation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in synaptic formation followed by maturation.