Synaptic formation and maturation regulated by membrane trafficking leading to higher function of the nervous system

RAB家族小G蛋白在囊泡转运过程中起着分子开关的作用。在本研究中，我们重点介绍了Rab3A、Rab13及其相关蛋白在突触形成和成熟中的作用和作用方式，从而导致神经系统的更高功能。对于Rab3A，我们发现缺少RabConnectin的小鼠表现出神经元功能障碍，这可能是由于突触组织的畸形所致。我们还发现，Rab13-JRAb系统调控着PC12细胞突起延伸过程中肌动蛋白细胞骨架的重组。我们的结果表明，在突触形成和成熟过程中，该系统可能同时协调囊泡运输和肌动蛋白细胞骨架重组。

Rab family small G proteins serve as molecular switches in the regulation of vesicular trafficking. In this study, we focus on the role and mode of action of Rab3A, Rab13, and their related proteins in synaptic formation and maturation, leading to higher function of the nervous system. As to Rab3A, we found the mice lacking Rabconnectin, the Rab3A-related protein, exhibit neuronal dysfunction, probably because of misformation of synaptic organization. We also found that the Rab13-JRAB system regulates the reorganization of actin cytoskeleton during neurite extension in PC12 cells. Our results suggest that this system may simultaneously coordinate vesicle transport and actin cytoskeletal reorganization in synaptic formation followed by maturation.