The role of exocytosis in biological functions

胞吐作用在生物功能中的作用

• 批准号: 24790285
• 负责人: SAKANE Ayuko
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790285/
• 关键词: 高次生命機能システム; エキソサイトーシス; 細胞間接着形成; 神経突起伸長・シナプス形成; Rabファミリー低分子量G蛋白質

Organization of individual cellular function as a whole system through receiving signals from extracellular environment and communicating with neighbors is vital for acquisition, expression, or maintenance of biological functions. Exocytosis, which is a one of main pathway of intracellular vesicular trafficking is taken as a pivotal factor to support the processes of the organization. In this study, we focus on the role of exocytosis in the formation of cell-cell contacts, neurite outgrowth, and the synapse formation leading to the organogenesis, or development and regeneration of neuronal system. We especially analyze the function of Rab family small G proteins and the related proteins and throw light on the molecular mechanisms of acquisition of biological functions.

通过接收来自细胞外环境的信号和与邻居的交流，将个体细胞功能组织成一个完整的系统，对于获取、表达或维持生物功能至关重要。胞吐作用是细胞内囊泡运输的主要途径之一，被认为是支持组织过程的关键因素。在这项研究中，我们着重于胞吐作用在细胞-细胞接触的形成、神经突起的生长以及导致器官发生或神经系统的发育和再生的突触形成中的作用。重点分析了Rab家族小G蛋白及其相关蛋白的功能，阐明了获得生物学功能的分子机制。

项目成果

Roles of Rab family small G proteins in formation of the apical junctional complex in epithelial cells Cell Polarity

Rab 家族小 G 蛋白在上皮细胞顶端连接复合物形成中的作用 细胞极性

• 发表时间: 2014
• 期刊: Biological Role and Basic Mechanisms
• 作者: Sakane A;and Sasaki T
• 通讯作者: and Sasaki T

動く細胞

移动细胞

• 发表时间: 2012
• 作者: 坂根亜由子;佐々木卓也
• 通讯作者: 佐々木卓也

Rab13 Small G Protein and Junctional Rab13-binding Protein (JRAB) Orchestrate Actin Cytoskeletal Organization during Epithelial Junctional Development

• DOI: 10.1074/jbc.m112.383653
• 发表时间: 2012-12-14
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Sakane, Ayuko;Abdallah, Ahmed Alamir Mahmoud;Sasaki, Takuya
• 通讯作者: Sasaki, Takuya

Expression of RASSF6 in kidney and the implication of RASSF6 and the Hippo pathway in the sorbitol-induced apoptosis in renal proximal tubular epithelial cells.

• DOI: 10.1093/jb/mvs056
• 发表时间: 2012-07
• 期刊: Journal of biochemistry
• 影响因子: 2.7
• 作者: Kanchanamala Withanage;K. Nakagawa;Mitsunobu Ikeda;H. Kurihara;Takumi Kudo;Zeyu Yang;A. Sakane;Takuya Sasaki;Y. Hata

Roles of Rab family small G proteins in formation of the apical junctional complex in epithelial cells

Rab家族小G蛋白在上皮细胞顶端连接复合物形成中的作用

• DOI: 10.1007/978-3-319-14463-4_15
• 发表时间: 2015
• 期刊: Cell Polarity: Biological Role and Basic Mechanisms
• 作者: Sakane;A. and Sasaki;T.
• 通讯作者: T.