Analysis of the molecular mechanism of CD44-mediated glucose metabolism in cancer cells for the development of new cancer therapy

分析癌细胞CD44介导的葡萄糖代谢分子机制，开发癌症新疗法

• 批准号: 22790326
• 负责人: NAGANO Osamu
• 金额: $ 2.5万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790326/
• 关键词: 癌; 遺伝子; 細胞・組織; 遺伝性

To examine whether the CD44-mediated modulation of glucose metabolism could be a new target for cancer therapy, we investigated the effect of CD44 expression on the activity of PKM2, a key enzyme for glycolysis. PKM2 was interacted with CD44 and such interaction increased the tyrosine phosphorylation of PKM2 leading to the augmentation of the glycolytic phenotype of cancer cells. Thus, CD44-mediated modulation of glycolysis pathway was found to be a new molecular target for cancer therapy.

为了研究CD44介导的葡萄糖代谢调节是否可以成为癌症治疗的新靶点，我们研究了CD44表达对糖酵解关键酶PKM 2活性的影响。PKM2与CD44相互作用，这种相互作用增加了PKM2的酪氨酸磷酸化，导致癌细胞糖酵解表型的增强。因此，发现CD44介导的糖酵解途径的调节是癌症治疗的新分子靶点。

项目成果

The role of CD44 in the expansion of gastric stem-like tumor cells

CD44在胃干样肿瘤细胞扩增中的作用

• 发表时间: 2010
• 作者: Tamada M;Nagano O;Tateyama S;Ohmura M;Yae T;Ishimoto T;Sugihara E;Onishi N;Yamamoto T;Yanagawa H;Suematsu M;Saya H;永野修;永野修;永野修;永野修;永野修;永野修;永野修;永野修;永野修
• 通讯作者: 永野修

CD44バリアントアイソフォームはシスチントランスポーターxCTの安定化を誘導し癌細胞の抗酸化システムを制御する

CD44 变异异构体诱导胱氨酸转运蛋白 xCT 的稳定并调节癌细胞中的抗氧化系统

• 发表时间: 2011
• 作者: Tamada M;Nagano O;Tateyama S;Ohmura M;Yae T;Ishimoto T;Sugihara E;Onishi N;Yamamoto T;Yanagawa H;Suematsu M;Saya H;永野修;永野修;永野修
• 通讯作者: 永野修

CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization

CD44 变异亚型通过胱氨酸转运蛋白 xCT 稳定调节癌细胞中的抗氧化状态

• 发表时间: 2011
• 作者: Tamada M;Nagano O;Tateyama S;Ohmura M;Yae T;Ishimoto T;Sugihara E;Onishi N;Yamamoto T;Yanagawa H;Suematsu M;Saya H;永野修
• 通讯作者: 永野修

Impact of CD44 Variant Form in Gastric Cancer

CD44 变体形式对胃癌的影响

• 发表时间: 2011
• 作者: Tamada M;Nagano O;Tateyama S;Ohmura M;Yae T;Ishimoto T;Sugihara E;Onishi N;Yamamoto T;Yanagawa H;Suematsu M;Saya H;永野修;永野修;永野修;永野修;永野修;永野修
• 通讯作者: 永野修

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

• DOI: 10.1158/0008-5472.can-11-3024
• 发表时间: 2012-03-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Tamada, Mayumi;Nagano, Osamu;Saya, Hideyuki
• 通讯作者: Saya, Hideyuki