NKG2D ligand expression and mechanism of immune escape from NKG2D-mediated surveillance in human inflammatory disease

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To understand the correlation between the expression profile of NKG2D ligands and various disorders in human, Immunohistochemical analyses were performed on human tissue specimens from several types of epithelial neoplasms and inflammatory disorders. Tissue-specificity concerning ligand expression patterns in epithelial neoplasms may be able to classify into at least three groups. Moreover, tissue-specificity concerning ligand dexpressin patterns in inflammatory disorders including autoimmune diseases may be similar with the tendency in the epithelial neoplasms.